FlyBase Allele Report: Dmel\lmd[1]

General Information

Symbol

Dmel\lmd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0129256

Feature type

allele

Associated gene

Dmel\lmd

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Duan et al., 2001)

Mutagen

ethyl methanesulfonate

(Duan et al., 2001)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q127term.

(Duan et al., 2001)

Nucleotide substitution: C?T.

(Duan et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:23,026,073..23,026,073 [-]

Nucleotide change:

C23026073T

Reported nucleotide change:

C?T

Amino acid change:

Q127term | lmd-PB

Reported amino acid change:

Q127term

(Duan et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Duan et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

The eve-expressing DA1 founder cell undergoes no fusion in lmd¹ embryos.

(Shelton et al., 2009)

Mutant embryos show widespread pericardial cell hyperplasia.

(Johnson et al., 2007)

The extent of myoblast fusion in lmd¹ mutant embryos is significantly reduced compared to wild type.

(Menon et al., 2005)

Defects in the somatic muscle lineage are seen in homozygous and lmd¹/Df(3R)M95A embryos, starting at late stage 12. Multinucleate Mhc-positive muscle fibres are not seen, instead only elongated, mononucleate Mhc-positive muscle cells are seen at late stage 15. Gut constrictions appear to be normal. Founder cells are present in mutant embryos but do not appear to undergo cell fusion (as occurs in wild-type embryos).

(Duan et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Other

Statement

Reference

lmd¹, trk^unspecified has embryonic/larval tracheal system | embryonic stage phenotype

(Wang et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

91553

red¹ e¹ lmd¹/TM3, P{ftz-lacZ.ry⁺}TM3, Sb¹ ry^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

lmd

(Popichenko et al., 2007)

lmd¹

(Schultheis et al., 2019, Zhou et al., 2019, Wang et al., 2018, Bonn et al., 2013, Cunha et al., 2010, Shelton et al., 2009, Duan et al., 2007, Estrada et al., 2007, Johnson et al., 2007, Duan and Nguyen, 2006, Estrada et al., 2006, Menon et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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