FlyBase Allele Report: Dmel\Cul4[KG02900]

General Information

Symbol

Dmel\Cul4^KG02900

Species

D. melanogaster

Name

FlyBase ID

FBal0130432

Feature type

allele

Associated gene

Dmel\Cul4

Associated Insertion(s)

P{SUPor-P}Cul4^KG02900

Carried in Construct

Also Known As

KG02900

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Cul4^KG02900

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:8,106,267..8,106,267 [+]

(Lee et al., 2010, Lin et al., 2009, Geng and MacDonald, 2007, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | somatic clone

(Lin et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Cul4^KG02900 mutant clones in sensory neurons in adult wing do not display any defects in injury-induced axon degeneration (following an axotomy, the severed axons are cleared away normally).

(Neukomm et al., 2017)

Hypomorphic Cul-4^KG02900 cells display normal levels of DNA content, judged by Hoechst labeling. Approximately 24.7% of Cul-4^KG02900 cells display normal levels of BrdU incorporation, while apoptosis and abnormal genome replication are largely suppressed. The percentage of mutant cells that incorporate either reduced or no BrdU at chorion gene foci is 71.8% while ectopic genome replication not detected in these cells.

(Lin et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Cul4^KG02900 is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Cul4^KG02900 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Cul4^KG02900 is a non-suppressor of abnormal neuroanatomy | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371

(Neukomm et al., 2017)

Cul4[+]/Cul4^KG02900 is a non-suppressor of visible phenotype of Scer\GAL4^sca.PU, mi^GD11624

(Szuplewski et al., 2012)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Cul4^KG02900 is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

NOT Suppressor of

Statement

Reference

Cul4^KG02900 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, cindr^{RNAi.PC.PD.UAS}

(Ketosugbo et al., 2017)

Cul4^KG02900 is a non-suppressor of sensory neuron | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371

(Neukomm et al., 2017)

Cul4^KG02900 is a non-suppressor of axon | somatic clone | adult stage phenotype of Sarm^{ΔARM.UAS.Tag:MYC}, Scer\GAL4^VGlut-OK371

(Neukomm et al., 2017)

Cul4[+]/Cul4^KG02900 is a non-suppressor of macrochaeta phenotype of Scer\GAL4^sca.PU, mi^GD11624

(Szuplewski et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The axon degeneration in sensory neurons clones in the adult wing expressing Ect4^{ΔARM.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^VGlut-OK371 can be suppressed by combination with Cul4^KG02900.

(Neukomm et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

13335

y¹; P{SUPor-P}Cul4^KG02900/CyO; ry⁵⁰⁶

Kyoto

111538

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{SUPor-P}Cul4^KG02900 /CyO y⁺

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Cul-4^KG02900

(Szuplewski et al., 2012)

Cul4^KG02900

(Wu et al., 2005)

cul-4^KG02900

(Christensen et al., 2008.12.28, Christensen et al., 2007.10.29)

cul4^KG02900

(Neukomm et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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