FB2024_03 , released June 25, 2024
Allele: Dmel\SmBBG02775
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General Information
Symbol
Dmel\SmBBG02775
Species
D. melanogaster
Name
FlyBase ID
FBal0130597
Feature type
allele
Associated gene
Dmel\SmB
Associated Insertion(s)
P{GT1}SmBBG02775
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{GT1}SmBBG02775
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{GT1}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      SmBSH0509/SmBBG02775 is partially rescued by Scer\GAL4Tub.PU/SmBUASp.cAa

      (Anne, 2010)

      SmBSH0509/SmBBG02775 is partially rescued by SmBR1-7.UASp/Scer\GAL4Tub.PU

      (Anne, 2010)

      SmBSH0509/SmBBG02775 is partially rescued by SmBR1-7K.UASp/Scer\GAL4Tub.PU

      (Anne, 2010)

      SmBSH0509/SmBBG02775 is partially rescued by Scer\GAL4Tub.PU/SmBR4-7.UASp

      (Anne, 2010)

      SmBSH0509/SmBBG02775 is partially rescued by SmBR4-7K.UASp/Scer\GAL4Tub.PU

      (Anne, 2010)

      SmBSH0509/SmBBG02775 is partially rescued by Scer\GAL4Tub.PU/SmBR1-3K.UASp

      (Anne, 2010)
      Comments

      Expression of SmBScer\UAS.P\T.cAa under the control of Scer\GAL4tub.PU rescues the lethality of SmBBG02775/SmBSH0509 with an efficiency of 61%.

      Expression of SmBR1-7.Scer\UAS.P\T under the control of Scer\GAL4tub.PU rescues the lethality of SmBBG02775/SmBSH0509 with an efficiency of 32%. However, all the rescued flies are completely agametic. Although germ cells can migrate through the midgut epithelium in these embryos, they are unable to coalesce with the gonadal mesoderm.

      Expression of SmBR1-7K.Scer\UAS.P\T under the control of Scer\GAL4tub.PU rescues the lethality of SmBBG02775/SmBSH0509 with an efficiency of 28%. However, all the rescued flies are completely agametic. Although germ cells can migrate through the midgut epithelium in these embryos, they are unable to coalesce with the gonadal mesoderm.

      Expression of SmBR4-7.Scer\UAS.P\T under the control of Scer\GAL4tub.PU rescues the lethality of SmBBG02775/SmBSH0509 with an efficiency of 37%. Rescued females have smaller ovaries than normal and contain mostly previtellogenic egg chambers. Most egg chambers that have reached the end of previtellogenic development show signs of degeneration, including a condensed nuclear morphology. Embryos derived from the few eggs laid by the rescued females build a normal layer of blastoderm cells, but fail to form pole cells.

      Expression of SmBR4-7K.Scer\UAS.P\T under the control of Scer\GAL4tub.PU rescues the lethality of SmBBG02775/SmBSH0509 with an efficiency of 30%. Rescued females have smaller ovaries than normal and contain mostly previtellogenic egg chambers. Most egg chambers that have reached the end of previtellogenic development show signs of degeneration, including a condensed nuclear morphology.

      Expression of SmBR1-3K.Scer\UAS.P\T under the control of Scer\GAL4tub.PU rescues the lethality of SmBBG02775/SmBSH0509 with an efficiency of 27%. The rescued animals have no gametes.

      (Anne, 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: a second-site lethal mutation.

      (Anne, 2010)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SmBBG02775
      (Hsieh et al., 2019, Anne, 2010, Anne et al., 2007)
      SmBBG
      (Hsieh et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)