UASp regulatory sequences drive expression of a ligand-inducible recombinase (P1cre::EBD) that is composed of the P1\cre recombinase coding region fused to the E ligand-binding domain of Hsap\ESR1.
In the presence of estrogen, animals carrying P1\creEBD304.Scer\UAS.P\T.T:Hsap\ESR1 expressed under the control of Scer\GAL4ey.PH may have rough eyes.
The T:Hsap\ESR1 hormone binding domain tag results in the level of recombinase activity being regulated by estrogen.