FB2024_03 , released June 25, 2024
Allele: Dmel\MbsEP3727
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General Information
Symbol
Dmel\MbsEP3727
Species
D. melanogaster
Name
FlyBase ID
FBal0131456
Feature type
allele
Associated gene
Dmel\Mbs
Associated Insertion(s)
P{EP}MbsEP3727
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Tan et al., 2003, Mizuno et al., 2002, Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}MbsEP3727
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MbsEP3727 flies have mild wing defects. Embryonic development in embryos derived from MbsEP3727/Df(3L)th117 females mated to wild-type males is normal in most cases. However, about 25% of embryos derived from MbsEP3727/Df(3L)th117 females mated to Mbs3/+ males fail to hatch. About 80% of the embryos that fail to hatch have a "dorsal open" phenotype, and in the remaining embryos the pattern of dorsal hairs is disturbed along the dorsal midline. The leading edge cells fail to fully elongate during dorsal closure, with some remaining polygonal, in Mbs mutant embryos derived from MbsEP3727/Df(3L)th117 females mated to Mbs3/+ males. The epidermal cells located more ventrally elongate nearly normally. There is an abnormal accumulation of F-actin within the leading edge cells, while its distribution along the leading edge is essentially unaffected.

      (Mizuno et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Mbs3/Df(3L)th117, MbsEP3727 has lethal | maternal effect | embryonic stage phenotype, suppressible by zip[+]/zipEbr

      (Mizuno et al., 2002)

      MbsEP3727/Df(3L)th117, Mbs3 has lethal | maternal effect | embryonic stage phenotype, suppressible by zip[+]/zipEbr

      (Mizuno et al., 2002)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      MbsEP3727, Scer\GAL4ey.3.5.Exel is a suppressor of eye phenotype of Scer\GAL4ey.3.5.Exel, kayFbz.UAS

      (Franciscovich et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of MbsEP3727 suppresses the small eye phenotype associated with kayFbz.Scer\UAS, when both are expressed under the control of Scer\GAL4ey.3.5.Exel.

      (Franciscovich et al., 2008)

      The lethality of Mbs mutant embryos derived from MbsEP3727/Df(3L)th117 females mated to Mbs3/+ males is suppressed by zipEbr/+.

      (Mizuno et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{EP} element can revert the wing phenotype. Strength of phenotype: Mbs3 = Mbs03802 > MbsP2r31 > MbsEP3727.

      (Mizuno et al., 2002)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CG5891EP3727
      DMBSP2
      (Mizuno et al., 2002)
      DMYPT3727
      (Tan et al., 2003)
      EP(3)3727
      (Mizuno et al., 2002)
      MbsEP3727
      Name Synonyms
      Secondary FlyBase IDs
        References (4)