FB2024_03 , released June 25, 2024
Allele: Dmel\Trxr1Δ2
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General Information
Symbol
Dmel\Trxr1Δ2
Species
D. melanogaster
Name
FlyBase ID
FBal0135774
Feature type
allele
Associated gene
Dmel\Trxr1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Missirlis et al., 2002)
Progenitor genotype
Trxr1G0477
(Missirlis et al., 2002)
Cytology
Description

Imprecise excision of the P{lacW} element resulting in a 534bp deletion corresponding to the N-terminal region of the mitochondrial Trxr-1 isoform.

(Missirlis et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes develop normally into the late third larval instar, but then die without undergoing metamorphosis. Adults are short lived and only live for a few days.

      (Missirlis et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      Trxr1G0481

      (Missirlis et al., 2002)
      Fails to complement

      Trxr1G0477

      (Missirlis et al., 2002)
      Rescued by

      Trxr1Δ2 is rescued by Scer\GAL4Act5C.PI/Trxr1mito.UAS

      (Missirlis et al., 2002)
      Not rescued by

      Trxr1Δ2 is not rescued by Trxr1cyto.UAS/Scer\GAL4Act5C.PI

      (Missirlis et al., 2002)
      Comments

      Expression of Trxr-1mito.Scer\UAS under the control of Scer\GAL4Act5C.PI restores the lifespan of Trxr-1Δ2 hemizygous males from a few days up to the range of the wild-type lifespan.

      (Missirlis et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Trxr-1Δ2
      Trxr1Δ2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)