FB2024_03 , released June 25, 2024
Allele: Dmel\ovo-2b
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General Information
Symbol
Dmel\ovo-2b
Species
D. melanogaster
Name
FlyBase ID
FBal0137124
Feature type
allele
Associated gene
Dmel\ovo
Associated Insertion(s)
Carried in Construct
P{ovo(-2b)}
Key Links
Transgenic product class
genomic_DNA
(Salles et al., 2002)
wild_type
(Salles et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Salles et al., 2002)
wild_type
(Salles et al., 2002)
Mutagen
in vitro construct
(Salles et al., 2002)
Progenitor genotype
Carried in construct
P{ovo(-2b)}
Cytology
Description

7kb SalI-HindIII genomic fragment containing ovo in which ovo nucleotides 3666-5338 have been replaced with the ovo cDNA sequences. The resulting construct lacks ovo exon 2b and intron IIb sequences.

(Salles et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
ovo
Encoded product / tool
ovo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      ovo-2b partially rescues ovoD1rv23

      (Salles et al., 2002)

      ovo-2b partially rescues ovoD1rv37

      (Salles et al., 2002)
      Comments

      ovoD1rv37 females carrying one copy of ovo-2b have small ovaries, with fewer ovarioles than normal. When egg chambers in these ovaries develop beyond stage 10, degeneration and apoptosis of nurse cells is seen. A few eggs are laid (5-10 per female per day) but they are flaccid. ovoD1rv37 females carrying two copies of ovo-2b contain a higher proportion of egg chambers which develop to maturity, but eggs which are laid fail to develop. ovoD1rv23 females carrying two copies of ovo-2b have ovaries with a variety of defects. Egg chambers in which follicle cells have failed to migrate and degenerating ovarioles are seen. Egg chambers develop to maturity in rare cases, giving rise to short, abnormal eggs which have ventralised eggshells and fused dorsal appendages.

      (Salles et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ovo-2b
      Name Synonyms
      Secondary FlyBase IDs
        References (1)