FB2024_03 , released June 25, 2024
Allele: Dmel\htsKG06777
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General Information
Symbol
Dmel\htsKG06777
Species
D. melanogaster
Name
FlyBase ID
FBal0137227
Feature type
allele
Associated gene
Dmel\hts
Associated Insertion(s)
P{SUPor-P}htsKG06777
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{SUPor-P}htsKG06777
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTT128Q.1-336.UAS
      (Kaltenbach et al., 2007)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      centrosome & spermatocyte (with Df(2R)BSC26)

      (Wilson, 2005)

      fusome & testis (with Df(2R)BSC26)

      (Wilson, 2005)

      germ cell & egg chamber (with Df(2R)BSC26)

      (Wilson, 2005)

      spindle & spermatocyte (with Df(2R)BSC26)

      (Wilson, 2005)
      Detailed Description
      Statement
      Reference

      Many egg chambers from htsKG06777/Df(2R)BSC26 frequently lack a full complement of germ cells.

      Gonial cells of htsKG06777/Df(2R)BSC26 testes rarely show branched fusome structures by immunostaining of Klp61F, although open ring structures (that probably correspond to the lumen of forming ring canals) are detected.

      In contrast to wild type, many spermatocytes in htsKG06777/Df(2R)BSC26 mutants contain too many or too few centrosomes.

      In contrast to wild type, 19% of meiotic spermatocytes in htsKG06777/Df(2R)BSC26 mutant testes show spindle abnormalities, including monopolar and multipolar spindles.

      (Wilson, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      htsKG06777 is a suppressor of visible phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

      (Kaltenbach et al., 2007)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      htsKG06777 is a suppressor of eye phenotype of Hsap\HTT128Q.1-336.UAS, Scer\GAL4GMR.PU

      (Kaltenbach et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Based on fusome assembly and immunoblot analysis, hts mutants can be placed in an allelic series from the most to the least severe: hts01103 > hts1 > htsKG06777 > htsk06121.

      (Wilson, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      KG06777
      (Kaltenbach et al., 2007)
      htsKG06777
      (Wilson, 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)