FlyBase Allele Report: Dmel\CanB2[180]

General Information

Symbol

Dmel\CanB2¹⁸⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0137570

Feature type

allele

Associated gene

Dmel\CanB2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

X ray

(Sullivan and Rubin, 2002)

ethyl methanesulfonate

(Sullivan and Rubin, 2002)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | larval stage | recessive

(Sullivan and Rubin, 2002)

lethal | pupal stage | recessive

(Sullivan and Rubin, 2002)

Phenotype Manifest In

dorsal longitudinal indirect flight muscle cell (with CanB2^EP774)

(Gajewski et al., 2003)

indirect flight muscle cell (with CanB2^EP774)

(Gajewski et al., 2003)

Detailed Description

Statement

Reference

In CanB2^EP774/CanB2¹⁸⁰ animals, large gaps or deletions occur in the centrally located dorsal medial muscle pairs. In most cases, one or more dorsal muscles are present, and on rare occasions, one or more ventral muscles. However, the dorsal ventral and trochanter muscle pairs are intact and normally arranged in these flies. In contrast to the precisely arrayed indirect flight muscles present in posterior thoraces of wild-type animals, the posterior thoraces of CanB2^EP774/CanB2¹⁸⁰ animals contain large, poorly defined muscle masses.

(Gajewski et al., 2003)

Lethality occurs at a late larval/pupal stage.

(Sullivan and Rubin, 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

CanB2¹⁸⁰ has lethal phenotype, suppressible by CanB^UAS.cSa/Scer\GAL4^hs.PB

(Sullivan and Rubin, 2002)

Suppressor of

Statement

Reference

CanB2¹⁸⁰ is a suppressor of visible phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Phenotype Manifest In

Suppressor of

Statement

Reference

CanB2¹⁸⁰ is a suppressor of eye phenotype of Pp2B-14D^act.GMR

(Sullivan and Rubin, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Low level expression of CanB^Scer\UAS.cSa under the control of Scer\GAL4^hs.PB (in the absence of heat shock) increases survival of CanB2¹⁸⁰ adults from less than 0.2% to 11%.

(Sullivan and Rubin, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a modifier of the Pp2B-14D^act.GMR rough eye phenotype.

(Sullivan and Rubin, 2002)

Comments

"X ray" was stated as tentative. "ethyl methanesulfonate" was stated as tentative.

(Sullivan and Rubin, 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CS2-1¹⁸⁰

(Sullivan and Rubin, 2002)

CanB2¹⁸⁰

canB2¹⁸⁰

(Gajewski et al., 2003)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close