FB2024_03 , released June 25, 2024
Allele: Dmel\hkbUAS.cMa
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General Information
Symbol
Dmel\hkbUAS.cMa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Myat
FlyBase ID
FBal0141092
Feature type
allele
Associated gene
Dmel\hkb
Associated Insertion(s)
Carried in Construct
P{UAS-hkb.M}
Also Known As
UAS-hkb
Key Links
Transgenic product class
wild_type
(Myat and Andrew, 2002)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Myat and Andrew, 2002)
Mutagen
in vitro construct
(Myat and Andrew, 2002)
Progenitor genotype
Carried in construct
P{UAS-hkb.M}
Cytology
Description

UASt regulatory sequences drive expression of the hkb coding region.

(Myat and Andrew, 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
hkb
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of hkbScer\UAS.cMa throughout the CNS, driven by Scer\GAL4sca-4512, induces the formation of additional glial cells, most of which appear to be subperineural glia.

      (De Iaco et al., 2006)

      Embryos expressing hkbScer\UAS.cMa under the control of Scer\GAL4fkh.PH do not show any change in either the order or number of salivary gland cells that change shape and invaginate, but later embryos show an expansion of the salivary gland lumen that increases in severity with age. Salivary gland cells of embryos expressing hkbScer\UAS.cMa under the control of Scer\GAL4fkh.PH have increased apical areas compared to wild type. At the ultrastructural level, more apical surface membrane is generated than normal.

      (Myat and Andrew, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of gcmScer\UAS.cBa and hkbScer\UAS.cMa in the embryonic CNS, driven by Scer\GAL4sca-4512, induces greater levels of additional subperineural glia than the expression of either transgene alone.

      (De Iaco et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      hkbScer\UAS.cMa
      hkbUAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Myat
      (Myat and Andrew, 2002)
      Secondary FlyBase IDs
        References (3)