FB2024_03 , released June 25, 2024
Allele: Dmel\Apc2f90
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General Information
Symbol
Dmel\Apc2f90
Species
D. melanogaster
Name
FlyBase ID
FBal0141948
Feature type
allele
Associated gene
Dmel\Apc2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Akong et al., 2002)
Mutagen
ethyl methanesulfonate
(McCartney et al., 2006, Akong et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q406term.

(McCartney et al., 2006)

Premature stop codon in Arm repeat.

(Akong et al., 2002)

Amino acid replacement: ??term.

(Akong et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:24,165,452..24,165,452 [+]
Nucleotide change:

C24165452T

Amino acid change:

Q406term | Apc2-PA; Q386term | Apc2-PB; Q406term | Apc2-PC

Reported amino acid change:

Q406term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(McCartney et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  familial adenomatous polyposis 1
      CEA with ApcQ8
      (Mendoza-Topaz et al., 2011)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The cuticle of an average Apc2g41 maternal/zygotic embryo shows an anterior hole, is 50-60% the length of wild-type and has at most 2 patches of denticles remaining.

      (McCartney et al., 2006)

      Asymmetric division of neuroblasts appear to be unaffected in the brains of Apc2g10/Apc2f90 larvae. Apc2f90 has a more severe maternal effect embryonic phenotype than either Apc2Σ or Apc2d40.

      (Akong et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos maternally and zygotically double mutant for ApcQ8 and Apc2f90 display a naked cuticle phenotype.

      Expression of AxnScer\UAS.T:Avic\GFP under the control of Scer\GAL4arm.PS is unable to restore normal-looking denticle belts in embryos that are maternally and zygotically mutant for ApcQ8 and Apc2f90. Every single embryo exhibits a completely naked cuticle, without any sign of denticle restoration.

      Expression of AxnScer\UAS.T:Avic\GFP under the control of Scer\GAL4arm.PS restores normal-looking denticle belts in embryos derived from females containing ApcQ8 Apc2f90 double mutant germline clones crossed with wild type males.

      Expressing AxnFGmut.Scer\UAS.T:Avic\GFP under the control of Scer\GAL4arm.PS does not suppress the naked cuticle phenotype seen in ApcQ8 Apc2f90 double mutant embryos. Only occasional individual denticles are seen.

      (Mendoza-Topaz et al., 2011)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Apc2ΔS

      (Akong et al., 2002)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Apc2 alleles can be divided into three categories based on their embryonic cuticle phenotypes, from weak to moderate to strong: Apc2e90 = Apc2b5 = Apc2N175K < Apc2c9 = Apc2ΔS = Apc2d40 < Apc2g41 = Apc2f90 = Apc2g10.

      (McCartney et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      APC2f90
      (McCartney et al., 2006, Akong et al., 2002)
      Apc2f90
      (Takacs et al., 2008)
      e-apcf90
      (Mendoza-Topaz et al., 2011)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)