FlyBase Allele Report: Dmel\wdb[14]

General Information

Symbol

Dmel\wdb¹⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0143112

Feature type

allele

Associated gene

Dmel\wdb

Associated Insertion(s)

P{EP}EP3559

Carried in Construct

Also Known As

wdb^EP3559

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Hannus et al., 2002)

P-element activity

(Hannus et al., 2002)

Progenitor genotype

P{EP}EP3559

(Hannus et al., 2002)

Associated Insertion(s)

P{EP}EP3559

Cytology

Description

In addition, the P{EP}wdb^EP3559 insertion is still present on the chromosome.

(Hannus et al., 2002)

Amino acid replacement: Y150term.

(Hannus et al., 2002)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:27,566,945..27,566,945 [-]

Nucleotide change:

C27566945R

Amino acid change:

Reported amino acid change:

Y150term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The P{EP}wdb^EP3559 insertion is also present on the chromosome.

(Hannus et al., 2002)

transposable_element_insertion_site

3R:27,582,191..27,582,191 [-]

(Hannus et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone

(Bhattacharjee et al., 2022)

abnormal planar polarity (with wdb^dw)

(Hannus et al., 2002)

lethal | recessive

(Hannus et al., 2002)

Phenotype Manifest In

dendrite | somatic clone

(Bhattacharjee et al., 2022)

multidendritic neuron | somatic clone

(Bhattacharjee et al., 2022)

wing hair (with wdb^dw)

(Hannus et al., 2002)

Detailed Description

Statement

Reference

The body weight of adult wdb¹⁴/wdb^dw flies is similar to controls.

wdb¹⁴/wdb^dw larvae have similar fat content and accumulation of lipid droplets in oenocytes compared to controls.

(Fischer et al., 2016)

wdb^dw/wdb¹⁴ transheterozygotes are viable and of normal size and weight.

(Fischer et al., 2015)

Overexpression of wdb¹⁴ under the control of Scer\GAL4^ap-md544 (using the P{EP}wdb^EP3559 insertion) results in no cells in the fifth wing cell having a multiple wing hair phenotype. Homozygous wdb¹⁴ clones have not been recovered. wdb^dw/wdb¹⁴ escapers have bald patches on the wing blade where hair formation has either failed or is compromised. The stunted hairs in these regions sometimes have altered polarity.

(Hannus et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

wdb¹⁴/wdb^dw is a suppressor of decreased body size | adult stage phenotype of CycG^HR7

(Fischer et al., 2016)

wdb¹⁴/wdb^dw is a suppressor of abnormal body size | adult stage phenotype of CycG^HR7

(Fischer et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

wdb¹⁴/wdb^dw is a suppressor of embryonic/larval oenocyte phenotype of CycG^HR7

(Fischer et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced body size and weight of CycG^HR7 homozygote adults is fully rescued by combination with wdb mutant alleles in a heteroallelic state: the CycG^HR7,wdb^dw/CycG^HR7,wdb¹⁴ flies have normal both body size and weight.

(Fischer et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wdb14

(Hannus et al., 2002)

wdb¹⁴

(Bhattacharjee et al., 2022, Rui et al., 2020, Wolterhoff et al., 2020, Fischer et al., 2016, Fischer et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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