FB2024_03 , released June 25, 2024
Allele: Dmel\savshrp-3
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General Information
Symbol
Dmel\savshrp-3
Species
D. melanogaster
Name
FlyBase ID
FBal0143234
Feature type
allele
Associated gene
Dmel\sav
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kango-Singh et al., 2002)
Mutagen
ethyl methanesulfonate
(Kango-Singh et al., 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q240term.

(Kango-Singh et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:23,060,466..23,060,466 [-]
Nucleotide change:

C23060466T

Amino acid change:

Q240term | sav-PA; Q240term | sav-PB

Reported amino acid change:

Q240term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kango-Singh et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      savshrp-3 mutants produce overgrown adult eyes.

      (Das Thakur et al., 2010)

      Mosaic animals in which the head is homozygous for savshrp-3 (made using the "eyFLP" technique) have enlarged heads, but patterning of the head cuticle is unaffected. The heads have folded head cuticle. Clones in the thorax result in overgrowth and clones in the haltere result in much larger halteres than normal. The number of cells in clones in the third larval instar wing disc is almost always larger than the number of cells in their wild-type twin clones. Cells in the mutant clones are normal in size.

      (Kango-Singh et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      savshrp-3 has visible | recessive phenotype, suppressible | partially by Df(1)jubI

      (Das Thakur et al., 2010)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      savshrp-3 has eye phenotype, suppressible | partially by Df(1)jubI

      (Das Thakur et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      A Df(1)djubI/+ genetic background reduces the magnitude of savshrp-3 eye phenotypes.

      (Das Thakur et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      savshrp-3
      savshrp3
      (Das Thakur et al., 2010)
      shrp3
      (Kango-Singh et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)