FB2024_03 , released June 25, 2024
Allele: Dmel\Syb21-15
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General Information
Symbol
Dmel\Syb21-15
Species
D. melanogaster
Name
FlyBase ID
FBal0144500
Feature type
allele
Associated gene
Dmel\Syb
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Bhattacharya et al., 2002)
Mutagen
ethyl methanesulfonate
(Bhattacharya et al., 2002, Goldstein et al., 2001)
diepoxybutane
(Goldstein et al., 2001)
gamma ray
(Goldstein et al., 2001)
Progenitor genotype
Cytology
Description

Amino acid replacement: W105term.

(Bhattacharya et al., 2002)

Nucleotide substitution: G?A.

(Bhattacharya et al., 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:10,250,947..10,250,947 [-]
Nucleotide change:

G10250947A

Reported nucleotide change:

G?A

Amino acid change:

W82term | Syb-PA; W105term | Syb-PB; W105term | Syb-PC; W82term | Syb-PD; W82term | Syb-PE

Reported amino acid change:

W105term

Comment:

G to A nucleotide change at the second or third position of the wild type Trp codon leads to a nonsense mutation (exact site of mutation unspecified). The mutation was annotated at the second base of the codon.

(Bhattacharya et al., 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mosaic animals in which the eyes are made homozygous for Syb21-15 fail to develop eyes and all or nearly all of the ommatidia are missing.

      (Bhattacharya et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Syb21-15 has eye | somatic clone phenotype, suppressible by Rat\Vamp2UAS.cBa/Scer\GAL4ey.PH

      (Bhattacharya et al., 2002)

      Syb21-15 has eye | somatic clone phenotype, suppressible by nSybhs.PB

      (Bhattacharya et al., 2002)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The failure of eye development seen in mosaic flies in which the eyes are homozygous for Syb21-15 is rescued by expression of n-sybhs.PB. The failure of eye development seen in mosaic flies in which the eyes are homozygous for Syb21-15 is rescued by expression of Rat\Vamp2Scer\UAS.cBa under the control of Scer\GAL4ey.PH.

      (Bhattacharya et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference

      The failure of eye development seen in mosaic flies in which the eyes are homozygous for Syb21-15 is rescued by expression of Rat\Vamp2Scer\UAS.cBa under the control of Scer\GAL4ey.PH.

      (Bhattacharya et al., 2002)
      Complementation and Rescue Data
      Rescued by

      Syb21-15 is rescued by Sybhs.PB

      (Bhattacharya et al., 2002)
      Comments

      The failure of eye development seen in mosaic flies in which the eyes are homozygous for Syb21-15 is rescued by expression of Sybhs.PB.

      (Bhattacharya et al., 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      "ethyl methanesulfonate" was stated as tentative. "diepoxybutane" was stated as tentative. "γ ray" was stated as tentative.

      (Goldstein et al., 2001)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      21-15
      (Goldstein, 2004.3.15, Goldstein et al., 2001)
      21.15
      (Goldstein, 2004.3.15)
      Syb21-15
      (Yamashita et al., 2022, Otte et al., 2009)
      Syb21
      (Otte et al., 2009)
      syb21-15
      (Bhattacharya et al., 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)