FB2024_03 , released June 25, 2024
Allele: Dmel\ptcN15
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General Information
Symbol
Dmel\ptcN15
Species
D. melanogaster
Name
FlyBase ID
FBal0146885
Feature type
allele
Associated gene
Dmel\ptc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Vegh and Basler, 2003)
Progenitor genotype
Cytology
Description

Amino acid replacement: G276D.

(Vegh and Basler, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,660,986..8,660,986 [+]
Nucleotide change:

G8660986A

Amino acid change:

G276D | ptc-PA

Reported amino acid change:

G276D

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Vegh and Basler, 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the wing induced by using Scer\FLP1Scer\UAS.cCa expressed under the control of Scer\GAL4vg.int2.1 result in disruption and duplication vein L4 and wing margin bristle defects. 14% of ptcN15/Df(2R)H3D3 animals survive to adulthood. Survivors show fusion of wing veins L3 and L4 and slight L3 defects.

      (Vegh and Basler, 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      ptcS2

      (Vegh and Basler, 2003)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      ptcN15
      Name Synonyms
      Secondary FlyBase IDs
        References (1)