Construct: Amino acid replacement: K228Q. Amino acid replacement: K231Q. Amino acid replacement: K257Q.
The reduction in electroretinogram (ERG) amplitude seen in flies exposed to constant light is greatly suppressed by Arr25/Arr23KQ. However, retinal degeneration and rate of loss of the deep pseudopupil in Arr25/Arr23KQ flies exposed to constant light is the same as that seen in wild-type flies exposed to constant light.
The termination of the electroretinogram (ERG) response to light is slower in Arr25 flies carrying Arr23KQ than in wild-type flies. Preexposure to white light for 10 minutes results in an increase in the rate of termination of the ERG (as occurs in wild-type flies), but the rate of termination is much slower than in wild-type flies.