FB2024_03 , released June 25, 2024
Allele: Dmel\Nmdar1UAS.Exel
Open Close
General Information
Symbol
Dmel\Nmdar1UAS.Exel
Species
D. melanogaster
Name
FlyBase ID
FBal0156145
Feature type
allele
Associated gene
Dmel\Nmdar1
Associated Insertion(s)
Carried in Construct
P{UAS-Nmdar1.Exel}
Key Links
Transgenic product class
wild_type
(Parks, 2004.5.12)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Parks, 2004.5.12)
Mutagen
in vitro construct
(Parks, 2004.5.12)
Progenitor genotype
Carried in construct
P{UAS-Nmdar1.Exel}
Cytology
Description

Wild type Nmdar1 coding sequences were cloned into P{Express-UAS}. May be missing amino acids 571-573, 833-855 and 965-969.

(Parks, 2004.5.12)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nmdar1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of Nmdar1Scer\UAS.Exel under the control of Scer\GAL4elav-C155 rescues changes in preference index (with respect to light) after constant darkness compared to overexpression flies reared in a normal light/dark cycle, indicating phototaxis preference behaviour plasticity is modulated by Nmdar1. These flies show normal ERG levels. Using Scer\GAL80ts.αTub84B to suppress expression of Nmdar1Scer\UAS.Exel until the flies are experiencing constant darkness reveals that Nmdar1 expression is critical to enable flies to respond with phototaxic plasticity. Overexpression of Nmdar1 also modulates adult phototaxis preference behavior plasticity.

      Overexpression of Nmdar1Scer\UAS.Exel under heat shock (Scer\GAL4hs.PB) rescues changes in preference index preference index (with respect to light) after constant darkness compared to overexpression flies reared in a normal light/dark cycle.

      (Zhou et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Nmdar1Scer\UAS.Exel
      Nmdar1UAS.Exel
      Name Synonyms
      Secondary FlyBase IDs
        References (2)