FB2024_03 , released June 25, 2024
Allele: Dmel\Rcc1XX138
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General Information
Symbol
Dmel\Rcc1XX138
Species
D. melanogaster
Name
FlyBase ID
FBal0157262
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Nature of the Allele
Progenitor genotype
Cytology
Description

Contains a large deletion from positions 1293 to 1738 and an insertion of two adenines. This results in a frame shift at the end of the fourth RCC1 repeat and a premature stop codon after a run of 33 additional irrelevant amino acids.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Inserted_sequence:

AA

Comment:

Contains a large deletion and an insertion of two adenines. This results in a frame shift at the end of the fourth RCC1 repeat and a premature stop codon after a run of 33 additional novel amino acids.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous mutant embryos exhibit an approximately 50% reduction of EL neurons with 3-5 ELs developing per abdominal hemisegment. These mutant embryos also exhibit morphological defects in the lateral CNS as the lateral margin of mutant nerve cords appear rough and scalloped relative to wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

Rcc1XX138 is a suppressor of ommatidium phenotype of hidGMR.PG

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Bj1XX138
Rcc1XX138
Name Synonyms
Secondary FlyBase IDs
    References (1)