FB2024_03 , released June 25, 2024
Allele: Dmel\TctpEY09182
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General Information
Symbol
Dmel\TctpEY09182
Species
D. melanogaster
Name
FlyBase ID
FBal0161363
Feature type
allele
Associated gene
Dmel\Tctp
Associated Insertion(s)
P{EPgy2}TctpEY09182
Carried in Construct
Also Known As
dTCTPEy09182, TctpEY
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Hong and Choi, 2013, Hsu et al., 2007)
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EPgy2}TctpEY09182
Cytology
Description

Insertion in the 5' untranslated region.

(Hsu et al., 2007)
Allele components
Component
Use(s)
Inserted element
P{EPgy2}
Regulatory region(s)
UASp
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Early embryos derived from homozygous females have mitotic defects such as chromosomal bridges and free centrosomes.

      TctpEY09182/Tctph59 flies show higher sensitivity to gamma irradiation compared to controls. Mitotic chromosomes from both larval brain neuroblasts and adult wing hair cells show more than twofold higher levels of double-strand break (DSB) repair defects after gamma irradiation in TctpEY09182/Tctph59 animals compared to controls.

      G2/M arrest after gamma irradiation is much reduced in TctpEY09182/Tctph59 mutants compared to controls, with the difference being most pronounced at a low dose of radiation (5 Gy). The intra-S checkpoint (as assayed by BrdU incorporation in the larval brain after irradiation) is reduced in TctpEY09182/Tctph59 mutants compared to wild type.

      (Hong and Choi, 2013)

      Rare homozygous escapers have a smaller body size than their heterozygous siblings.

      (Hsu et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      TctpEY09182 is an enhancer of abnormal DNA repair | larval stage phenotype of tefuatm-3

      (Hong and Choi, 2013)

      TctpEY09182 is an enhancer of abnormal cell cycle | larval stage phenotype of tefuatm-3

      (Hong and Choi, 2013)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygosity for TctpEY09182 enhances the chromosome aberrations seen in brain neuroblasts of tefuatm-3 larvae (18.0% fused chromosomal arms, 7.9% double-strand breaks).

      (Hong and Choi, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Tctph59/TctpEY09182 is rescued by Tctp+tGe

      (Hong and Choi, 2013)
      Comments

      Tctp+tGe rescues the increased sensitivity of TctpEY09182/Tctph59 flies to gamma irradiation.

      (Hong and Choi, 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Separable from: l(3)EY09182EY09182.

      (Cook, 2006.10.1)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      CG4800EY09182
      TctpEY09182
      (Kim et al., 2023, Hong and Choi, 2016, Cook, 2006.10.1)
      TctpEY
      (Kim et al., 2023, Hong and Choi, 2016)
      dTCTPEY09182
      (Hong and Choi, 2013)
      dTCTPEy09182
      (Hsu et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)