FB2024_03 , released June 25, 2024
Allele: Dmel\Ptipc04574
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General Information
Symbol
Dmel\Ptipc04574
Species
D. melanogaster
Name
FlyBase ID
FBal0161698
Feature type
allele
Associated gene
Dmel\Ptip
Associated Insertion(s)
PBac{PB}Ptipc04574
Carried in Construct
Also Known As
PBacptip
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Fang et al., 2009)
Mutagen
piggyBac activity
(Bloomington Drosophila Stock Center, 2004.11.6)
Progenitor genotype
Associated Insertion(s)
PBac{PB}Ptipc04574
Cytology
Description

Insertion in the fifth exon.

(Fang et al., 2009)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Two classes of phenotype are seen in embryos derived from females containing homozygous ptipc04574 germline clones mated to Df(3L)fz-GF3b/+ males. Embryos that are both maternally and zygotically mutant for ptip show severe disruption or complete loss of denticle belts. Embryos that lack maternal ptip function have fairly normal cuticle patterns, although they often have denticle fusions.

      ptipc04574/Df(3L)fz-GF3b zygotic mutant third instar larvae are normal in overall size and show normal locomotion. However, the imaginal discs are smaller than normal and are distorted.

      (Fang et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Df(3L)fz-GF3b/Ptipc04574 has lethal phenotype, suppressible by Mmus\Paxip1UAS.cFa/Scer\GAL4hs.PB

      (Fang et al., 2009)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Mmus\Paxip1Scer\UAS.cFa under the control of Scer\GAL4hs.PB using heat shock rescues the lethality of ptipc04574/Df(3L)fz-GF3b zygotic mutants.

      (Fang et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CG32133c04574
      PBacptip
      (Cheng et al., 2022, Fang et al., 2009)
      Ptipc04574
      ptipc04574
      Name Synonyms
      Secondary FlyBase IDs
        References (4)