FB2024_03 , released June 25, 2024
Allele: Dmel\sotv44
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General Information
Symbol
Dmel\sotv44
Species
D. melanogaster
Name
FlyBase ID
FBal0176154
Feature type
allele
Associated gene
Dmel\sotv
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Han et al., 2004)
Mutagen
ethyl methanesulfonate
(Han et al., 2004)
Progenitor genotype
Cytology
Description

The start codon of Ext2 is mutated from ATG to ATA.

(Han et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:16,148,655..16,148,655 [-]
Nucleotide change:

G16148655A

Reported nucleotide change:

G?A

Amino acid change:

M1I | sotv-PB

Reported amino acid change:

M1I

(Han et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wings bearing Ext244/Ext244 somatic clones exhibit a variety of phenotypes, including vein loss, vein fusion, blistering, narrowed wings and wing notching. The cuticles of Ext244/Ext244 embryos from Ext244/Ext244 germ-line clones have weak segment-polarity phenotypes. Animals zygotically mutant for Ext244 survive until the third instar larval stage and appear to have normal cuticle patterning.

      (Han et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Originated in screen described in FBrf0151913.

      (Han et al., 2004)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ext244
      sotv44
      (Glise et al., 2005, Han et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)