FB2024_03 , released June 25, 2024
Allele: Dmel\pertim.Aa
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General Information
Symbol
Dmel\pertim.Aa
Species
D. melanogaster
Name
FlyBase ID
FBal0178457
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
P{tim-per.A}
Key Links
Transgenic product class
cDNA
(Ashmore et al., 2003)
wild_type
(Ashmore et al., 2003)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ashmore et al., 2003)
wild_type
(Ashmore et al., 2003)
Mutagen
in vitro construct
(Ashmore et al., 2003)
Progenitor genotype
Carried in construct
P{tim-per.A}
Cytology
Description

Construct: tim promoter drives expression of per cDNA.

(Ashmore et al., 2003)
Allele components
Component
Use(s)
Regulatory region(s)
tim
Encoded product / tool
per
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The pertim.Aa transgene causes shortened circadian rhythms. The severity of this depends on transgene copy number and position of insertion; the most severe effect is to shorten the fly's day to 22 hours and decrease the proportion of rhythmic flies.

      (Ashmore et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      pertim.Aa has abnormal circadian rhythm phenotype, non-enhanceable by timmTim4

      (Ashmore et al., 2003)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of timmTim4 into flies with a pertim.Aa background does not further shorten the circadian period of flies.

      (Ashmore et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      pertim.Aa partially rescues per01

      (Ashmore et al., 2003)
      Comments

      pertim.Aa rescues circadian rhythms in per01 flies to a period that is 1-2 hours shorter than wild type.

      (Ashmore et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pertim.Aa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)