FB2024_03 , released June 25, 2024
Allele: Dmel\Lk615
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General Information
Symbol
Dmel\Lk615
Species
D. melanogaster
Name
FlyBase ID
FBal0182932
Feature type
allele
Associated gene
Dmel\Lk6
Associated Insertion(s)
P{EP}EP30.18
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Reiling et al., 2005)
Progenitor genotype
P{EP}EP30.18
(Reiling et al., 2005)
Associated Insertion(s)
P{EP}EP30.18
Cytology
Description

The progenitor P{EP}EP30.18 insertion is also still present on the chromosome.

(Reiling et al., 2005)

Frame shift at position 362, resulting in translation termination after twelve additional amino acids (FFSGGRVARCQR) (revision of data reported in FBrf0183826).

(Reiling et al., 2005)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous flies are normal in size. Homozygous clones induced in the imaginal discs show growth behaviour indistinguishable from that of their neighbouring twin spot clones. Homozygous flies raised on reduced yeast levels (30% yeast compared to standard food medium) show a significant weight reduction (9% in males and 20% in females) compared to flies reared on standard fly medium (100% yeast) (wild-type flies do not show this reduction in weight at reduced yeast levels). The reduced size in the mutant flies is due to a reduction in cell number, as cell size is unaffected in adult wings. Further reduction of the yeast content (to 20%) results in a more pronounced weight loss in the mutant flies, which is caused by a reduction in both cell size and cell number. Under starvation conditions, homozygous females live nearly 50% longer than control flies and homozygous males live 22% longer than control flies.

      (Reiling et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Lk615
      Name Synonyms
      Secondary FlyBase IDs
        References (2)