FB2024_03 , released June 25, 2024
Allele: Dmel\H15nmr-210
Open Close
General Information
Symbol
Dmel\H15nmr-210
Species
D. melanogaster
Name
FlyBase ID
FBal0183343
Feature type
allele
Associated gene
Dmel\H15
Associated Insertion(s)
Carried in Construct
Also Known As
nmr1210
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Leal et al., 2009, Qian et al., 2005)
Mutagen
Delta2-3 transposase
(Qian et al., 2005)
Progenitor genotype
P{PZ}H-15
(Qian et al., 2005)
Cytology
Description

Imprecise excision of the P{PZ} element, resulting in a 10911bp deletion of H15, from -331bp to +10580bp, which the 5'UTR, transcription and translation start sites and the entire DNA binding domain.

(Qian et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:5,404,011..5,414,921 [+]
Comment:

Inferred boundaries of a 10,911 bp deletion resulting from the imprecise excision of P{PZ}H-15, which is reported to extend from the site of the insertion 331 bp upstream of the H15 transcription start site to 10,588 bases beyone the start site. The start site was not unambiguously defined.

(Qian et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuronal cell fate specification progresses normally in the central nervous system of homozygous H15nmr-210 embryos.

      (Leal et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Embryos doubly mutant for H15nmr-210 and exexKK30 do not show enhancement of the respective single mutant central nervous system phenotypes.

      (Leal et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      H15nmr-210
      nmr1210
      (Leal et al., 2009, Qian et al., 2008)
      nmr210
      (Kumar et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)