FB2024_03 , released June 25, 2024
Allele: Dmel\DarkP46
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General Information
Symbol
Dmel\DarkP46
Species
D. melanogaster
Name
FlyBase ID
FBal0191765
Feature type
allele
Associated gene
Dmel\Dark
Associated Insertion(s)
Carried in Construct
Also Known As
arkP46
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Srivastava et al., 2007, Arama et al., 2006)
Mutagen
ethyl methanesulfonate
(Srivastava et al., 2007, Arama et al., 2006)
Progenitor genotype
Cytology
Description

Sequencing of the coding region of this allele reveals no lesions, suggesting that it may harbor a mutation in a regulatory element.

(Arama et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dark82/DarkP46 transheterozygotes do not exhibit a significant proportion of hyperplastic testes, as compared to controls.

      (Napoletano et al., 2017)

      ArkN28/ArkP46 mutant males exhibit a marked increase in spermatogonial cyst death compared to controls.

      ArkP46/Ark82 mutant males exhibit a marked increase in spermatogonial cyst death compared to controls.

      (Yacobi-Sharon et al., 2013)

      ArkP46 mutants display severe defects during the spermatid individualization process. The cystic bulges are frequently reduced in size or appear flat due to a failure in the appropriate collection of the cytoplasm of the spermatids . The retained cytoplasm is clearly visualized as a trail along the entire length of what was supposed to have been the post-individualized portion of the spermatids. Frequently a large portion of the spermatid cytoplasm is retained in a 'mini' cystic bulge structure, which often contains part of the individualization complex. Waste bags are also reduced in size.

      (Arama et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      DarkP46 is a suppressor of eye phenotype of hidGMR.PG

      (Srivastava et al., 2007)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The WGMR.PG eye ablation phenotype is strongly suppressed when eyes carry homozygous clones for ArkP46.

      (Srivastava et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Selected as: a mutant that recessively suppresses the eye ablation phenotype caused by eye-specific overexpression of W.

      (Arama et al., 2006)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      ArkP46
      DarkP46
      P46
      (Srivastava et al., 2007)
      arkP46
      (Yacobi-Sharon et al., 2013, Srivastava et al., 2007)
      darkP46
      (Napoletano et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)