FB2024_03 , released June 25, 2024
Allele: Dmel\abd-ARNAi.UAS.cMa
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General Information
Symbol
Dmel\abd-ARNAi.UAS.cMa
Species
D. melanogaster
Name
FlyBase ID
FBal0191799
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of abd-A dsRNA.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

abdominal segment 1 & puparium & myoblast, with Scer\GAL4how-24B

abdominal segment 1 & puparium & myoblast, with Scer\GAL4NP5169

abdominal segment 1 & puparium & myofibril, with Scer\GAL4how-24B

abdominal segment 1 & puparium & myofibril, with Scer\GAL4NP5169

abdominal segment 2 & puparium & myoblast, with Scer\GAL4how-24B

abdominal segment 2 & puparium & myoblast, with Scer\GAL4NP5169

abdominal segment 2 & puparium & myofibril, with Scer\GAL4how-24B

abdominal segment 2 & puparium & myofibril, with Scer\GAL4NP5169

abdominal segment 3 & puparium & myoblast, with Scer\GAL4how-24B

abdominal segment 3 & puparium & myoblast, with Scer\GAL4NP5169

abdominal segment 3 & puparium & myofibril, with Scer\GAL4how-24B

abdominal segment 3 & puparium & myofibril, with Scer\GAL4NP5169

abdominal segment 4 & puparium & myoblast, with Scer\GAL4how-24B

abdominal segment 4 & puparium & myoblast, with Scer\GAL4NP5169

abdominal segment 4 & puparium & myofibril, with Scer\GAL4how-24B

abdominal segment 4 & puparium & myofibril, with Scer\GAL4NP5169

abdominal segment 5 & puparium & myoblast | ectopic, with Scer\GAL4how-24B

abdominal segment 5 & puparium & myoblast | ectopic, with Scer\GAL4NP5169

abdominal segment 5 & puparium & myofibril, with Scer\GAL4how-24B

Detailed Description
Statement
Reference

Induction of abd-AdsRNA.Scer\UAS.cMa, under the control of the pan-myogenic Scer\GAL4how-24B (and Scer\GAL80ts.αTub84B, placed at the restrictive temperature of 29oC at the onset of metamorphosis) completely prevents terminal chamber differentiation. In particular, the organisation of the myofibrils in segment A5 is unmodified at metamorphosis. The fibrils remain oriented transversally, as in the larval heart, instead of being remodelled and longitudinally oriented. Induction of abd-AdsRNA.Scer\UAS.cMa, under the control of the pan-myogenic Scer\GAL4how-24B (and Scer\GAL80ts.αTub84B, placed at the restrictive temperature of 29oC at the onset of metamorphosis) prevents the formation of nerve terminations, without affecting axon growth. Induction of abd-AdsRNA.Scer\UAS.cMa, under the control of the pan-myogenic Scer\GAL4how-24B in the cardiac tube does not affect the histolysis of segments A6 and A7, which are eliminated upon abd-AdsRNA.Scer\UAS.cMa induction. Induction of abd-AdsRNA.Scer\UAS.cMa, under the control of either the pan-myogenic Scer\GAL4how-24B, or the heart-specific Scer\GAL4NP5169 (both with Scer\GAL80ts.αTub84B, placed at the restrictive temperature of 29oC at the onset of metamorphosis), leads to an almost complete transformation of segments A1-A4 into structures characteristic of the terminal chamber. This transformation is characterised by the thinning of the cardiac tube and the longitudinal orientation of the myocyte muscle fibers.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
abd-ARNAi.UAS.cMa
abd-AdsRNA.Scer\UAS.cMa
abd-AdsRNA.UAS.cMa
Name Synonyms
Secondary FlyBase IDs
    References (3)