Contains a small deletion after amino acid residue N164, which causes a frameshift into a short heterologous peptide LTVNTISTNL.
r2d2S165fsX mutants display a reduction in dsRNA processing and a subsequent ~40% reduction in siRNA levels.
r2d2S165fsX flies show increased mortality and an increased level of viral accumulation following infection with both Flock house virus (FHV) and cricket paralysis virus (CrPV).
r2d2S165fsX is a suppressor of eye phenotype of wRNAi.GMR
r2d2S165fsX/loqsKO is a suppressor of eye phenotype of wRNAi.GMR
r2d2S165fsX mutant flies carrying two copies of wIR.GMR exhibit impaired w silencing and display orange-red eyes.
loqsKO r2d2S165fsX double mutant flies carrying two copies of wIR.GMR exhibit impaired w silencing and display orange-red eyes.
loqsKO r2d2S165fsX double mutants display a reduction in dsRNA processing and a subsequent ~80% reduction in siRNA levels.