FB2024_03 , released June 25, 2024
Allele: Dmel\SurRNAi.UAS.1-2
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General Information
Symbol
Dmel\SurRNAi.UAS.1-2
Species
D. melanogaster
Name
FlyBase ID
FBal0194195
Feature type
allele
Associated gene
Dmel\Sur
Associated Insertion(s)
Carried in Construct
P{UAS-Sur.RNAi.1-2}
Key Links
Transgenic product class
RNAi_reagent
(Akasaka et al., 2006)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Akasaka et al., 2006)
Mutagen
in vitro construct
(Akasaka et al., 2006, Akasaka et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Sur.RNAi.1-2}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat (in tail-to-tail orientation) of a 584 bp XbaI fragment of Sur amplified from cDNA clone SD08664.

(Akasaka et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sur
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing SurdsRNA.Scer\UAS.1-2 under the simultaneous control of both Scer\GAL4tin.cBa and Scer\GAL4Scer\UAS.cHa show reduced survival after challenge with flock house virus than control flies.

      Flies expressing SurdsRNA.Scer\UAS.1-2 under the control of Scer\GAL4hs.PB show reduced survival after challenge with flock house virus than control flies.

      Expression of SurdsRNA.Scer\UAS.1-2 under the control of Scer\GAL4NP3084 has no effect on the resistance of flies to infection with flock house virus.

      (Croker et al., 2007)

      1-week old progeny expressing SurdsRNA.Scer\UAS.1-2 under the simultaneous control of Scer\GAL4tin.cBa and Scer\GAL4Scer\UAS.cHa exhibit an increased rate of pacing-induced heart failure compared with controls.

      Young pupae co-expressing two insertion lines of P{UAS-Sur.RNAi.1-2} (P{UAS-Sur.RNAi.1-2}1 and P{UAS-Sur.RNAi.1-2}2) under the simultaneous control of Scer\GAL4twi.PG and Scer\GAL4how-24B, or under the simultaneous control of Scer\GAL4tin.cBa and Scer\GAL4Scer\UAS.cHa, show a significant delay in heart rate recovery after hypoxic stress compared to controls.

      (Akasaka et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SurRNAi.UAS.1-2
      SurdsRNA.Scer\UAS.1-2
      SurdsRNA.UAS.1-2
      Name Synonyms
      Secondary FlyBase IDs
        References (5)