FlyBase Allele Report: Dmel\Dark[G8]

General Information

Symbol

Dmel\Dark^G8

Species

D. melanogaster

Name

FlyBase ID

FBal0194627

Feature type

allele

Associated gene

Dmel\Dark

Associated Insertion(s)

Carried in Construct

Also Known As

ark^G8

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Srivastava et al., 2007, Herz et al., 2006)

Mutagen

ethyl methanesulfonate

(Srivastava et al., 2007)

Progenitor genotype

Cytology

Description

Amino acid replacement: C346W.

(Srivastava et al., 2007, Herz et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2R:17,022,612..17,022,612 [+]

Nucleotide change:

T17022612G

Amino acid change:

C346W | Dark-PA; C346W | Dark-PB

Reported amino acid change:

C346W

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Srivastava et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | embryonic stage | germline clone

(Srivastava et al., 2007)

lethal - all die before end of pupal stage | recessive

(Srivastava et al., 2007)

some die during pupal stage | recessive

(Srivastava et al., 2007)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ark^G8 mutants show a strong reduction in embryonic cell death.

(Srivastava et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Dark^G8 is a suppressor | somatic clone of increased cell death | third instar larval stage phenotype of p53^GMR.Ex

(Fan et al., 2010)

Dark^G8 is a suppressor of increased cell death | larval stage phenotype of hid^GMR.PG

(Srivastava et al., 2007)

NOT Suppressor of

Statement

Reference

Dark^G8 is a non-suppressor of abnormal neuroanatomy | adult stage | progressive | conditional phenotype of norpA^EE5

(Chinchore et al., 2012)

Phenotype Manifest In

Suppressor of

Statement

Reference

Dark^G8 is a suppressor | somatic clone of eye disc | posterior | third instar larval stage phenotype of p53^GMR.Ex

(Fan et al., 2010)

Dark^G8 is a suppressor of eye phenotype of hid^GMR.PG

(Srivastava et al., 2007)

NOT Suppressor of

Statement

Reference

Dark^G8 is a non-suppressor of retina | progressive | conditional phenotype of norpA^EE5

(Chinchore et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Induction of Ark^G8 third instar larval eyes disc clones blocks the cell death seen in p53^GMR.Ex mutants.

(Fan et al., 2010)

The W^GMR.PG eye ablation phenotype is strongly suppressed when eyes carry homozygous clones for Ark^G8.

The elevated apoptosis in W^GMR.PG eye discs is significantly reduced when eyes carry homozygous Ark^G8 clones.

(Srivastava et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ark^G8

Dark^G8

(Srivastava et al., 2007)

ark^G8

(Chinchore et al., 2012, Fan et al., 2010, Srivastava et al., 2007, Herz et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close