FB2024_03 , released June 25, 2024
Allele: Dmel\Mkp3M76-R2b
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General Information
Symbol
Dmel\Mkp3M76-R2b
Species
D. melanogaster
Name
FlyBase ID
FBal0194674
Feature type
allele
Associated gene
Dmel\Mkp3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Cela and Llimargas, 2006, Ruiz-Gomez et al., 2005)
Mutagen
ethyl methanesulfonate
(Ruiz-Gomez et al., 2005)
Progenitor genotype
Mkp3EP-M76
(Cela and Llimargas, 2006)
Cytology
Description

Amino acid replacement: M1K.

(Ruiz-Gomez et al., 2005)

Mutation of the first translation codon from ATG to AAG.

(Ruiz-Gomez et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:19,085,722..19,085,722 [-]
Nucleotide change:

T19085722A

Reported nucleotide change:

T?A

Amino acid change:

M1K | Mkp3-PB; M1K | Mkp3-PC; M1K | Mkp3-PD

Reported amino acid change:

M1K

(Ruiz-Gomez et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mkp3M76-R2b suppresses the embryonic tracheal branching defects of Scer\GAL4btl.PS>Mkp3GSM76 embryos.

      Mkp3M76-R2b embryos exhibit a mild delay in tracheal branching.

      (Cela and Llimargas, 2006)

      Mkp3M76-R2b homozygotes and Mkp3M76-M/Mkp3M76-R2b transheterozygotes have ectopic wing vein tissue differentiated in the proximal region between veins L4 and L5 and in other wing territories.

      (Ruiz-Gomez et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Mkp3M76-R2b/Mkp3[+] is an enhancer of visible | adult stage phenotype of Scer\GAL4MD-638, tayRNAi.UAS

      (Molnar and de Celis, 2013)
      NOT Enhancer of
      Statement
      Reference

      Mkp3M76-R2b is a non-enhancer of visible phenotype of Scer\GAL4nub-AC-62, tayEP-866

      (Molnar and de Celis, 2013)
      NOT Suppressor of
      Statement
      Reference

      Mkp3M76-R2b is a non-suppressor of visible phenotype of Scer\GAL4nub-AC-62, tayEP-866

      (Molnar and de Celis, 2013)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Mkp3M76-R2b/Mkp3[+] is an enhancer of wing vein | ectopic phenotype of Scer\GAL4MD-638, tayRNAi.UAS

      (Molnar and de Celis, 2013)
      NOT Enhancer of
      Statement
      Reference

      Mkp3M76-R2b is a non-enhancer of wing phenotype of Scer\GAL4nub-AC-62, tayEP-866

      (Molnar and de Celis, 2013)

      Mkp3M76-R2b is a non-enhancer of wing vein phenotype of Scer\GAL4nub-AC-62, tayEP-866

      (Molnar and de Celis, 2013)
      NOT Suppressor of
      Statement
      Reference

      Mkp3M76-R2b is a non-suppressor of wing phenotype of Scer\GAL4nub-AC-62, tayEP-866

      (Molnar and de Celis, 2013)

      Mkp3M76-R2b is a non-suppressor of wing vein phenotype of Scer\GAL4nub-AC-62, tayEP-866

      (Molnar and de Celis, 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      One copy of Mkp3M76-R2b enhances the wing vein phenotype seen when taydsRNA.Scer\UAS is expressed under the control of Scer\GAL4MD-638.

      A Mkp3M76-R2b mutant background does not modify the loss of wing veins and reduction in wing size seen when tayEP-866 is expressed in the entire wing blade and hinge under the control of Scer\GAL4nub-AC-62.

      (Molnar and de Celis, 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MKP3R2b
      (Molnar et al., 2018)
      Mkp3M76-R2b
      (Molnar et al., 2018, Molnar and de Celis, 2013, Cela and Llimargas, 2006, Ruiz-Gomez et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)