FlyBase Allele Report: Dmel\SMC1[exc46]

General Information

Symbol

Dmel\SMC1^exc46

Species

D. melanogaster

Name

FlyBase ID

FBal0195335

Feature type

allele

Associated gene

Dmel\SMC1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Schuldiner et al., 2008)

Mutagen

Progenitor genotype

Cytology

Description

Deletion encompassing SMC1.

(Schuldiner et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | somatic clone

(Schuldiner et al., 2008)

lethal

(Dorsett et al., 2005)

lethal (with Df(3R)Exel6197)

(Jacobs, 2018.7.9)

lethal - all die before end of second instar larval stage | recessive

(Gause et al., 2010)

some die during second instar larval stage | recessive

(Gause et al., 2010)

Phenotype Manifest In

adult mushroom body | somatic clone

(Schuldiner et al., 2008)

condensed chromosome

(Dorsett et al., 2005)

Detailed Description

Statement

Reference

SMC1^exc46/Df(3R)Exel6197 transheterozygotes are lethal.

SMC1^exc46 homozygous embryos do not show an obvious musculature phenotype, as compared to controls.

(Jacobs, 2018.7.9)

Chromosomal squashes of SMC1^exc46 mutants reveal precocious sister chromatid separation.

(Dorsett et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

SMC1^exc46 is a suppressor of sex comb | ectopic phenotype of Pc¹

(Schaaf et al., 2013)

SMC1^exc46 is a suppressor of sex comb | ectopic phenotype of Sce¹

(Schaaf et al., 2013)

SMC1^exc46/SMC1[+] is a suppressor of wing margin phenotype of ct^K

(Dorsett et al., 2005)

NOT Suppressor of

Statement

Reference

SMC1^exc46 is a non-suppressor of sex comb | ectopic phenotype of Pc⁶

(Schaaf et al., 2013)

SMC1^exc46 is a non-suppressor of sex comb | ectopic phenotype of Psc¹

(Schaaf et al., 2013)

SMC1^exc46 is a non-suppressor of sex comb | ectopic phenotype of ph-d⁴⁰¹

(Schaaf et al., 2013)

SMC1^exc46 is a non-suppressor of abdominal segment | adult stage phenotype of ph-d⁴⁰¹

(Schaaf et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

SMC1^exc46 is rescued by SMC1^Chi.EGFP

(Gause et al., 2010)

Comments

SMC1^exc46 homozygotes expressing SMC1^{Chi.T:Avic\GFP-EGFP} survive to adulthood.

(Gause et al., 2010)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

25718

y¹ w^*; SMC1^exc46/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

SMC1^exc46

(Das et al., 2016)

SMC1^Δexc46

(Schuldiner et al., 2008)

Smc1^exc46

(Schaaf et al., 2013, Hallson et al., 2008)

smc1^ex46

(Perkins et al., 2019)

smc1^exc46

(Colmenares et al., 2017, Gause et al., 2010, Dorsett et al., 2005)

smc1Δ

(Perkins et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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