FB2024_03 , released June 25, 2024
Allele: Dmel\moody+tgenα
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General Information
Symbol
Dmel\moody+tgenα
Species
D. melanogaster
Name
FlyBase ID
FBal0195783
Feature type
allele
Associated gene
Dmel\moody
Associated Insertion(s)
Carried in Construct
P{moody+tgenα}
Also Known As
genα
Key Links
Transgenic product class
wild_type
(Bainton et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bainton et al., 2005)
Mutagen
in vitro construct
(Bainton et al., 2005)
Progenitor genotype
moody+t9.4
(Bainton et al., 2005)
Carried in construct
P{moody+tgenα}
Cytology
Description

A 3kb SacII-XbaI fragment has been replaced with an equivalent fragment from a moody cDNA with prespliced fourth introns, which corresponds to the RA, or alpha) transcript.

(Bainton et al., 2005)
Allele components
Component
Use(s)
Regulatory region(s)
moody
Encoded product / tool
moody
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies that express moody+tgenα in a Df(1)moody-Δ17 background show increased cocaine sensitivity, as measured by their behaviour in response to the drug.

      (Bainton et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      moody+tgenα partially rescues Df(1)moody-Δ17

      (Bainton et al., 2005)

      moody+tgenα partially rescues Df(1)moody-Δ17

      (Schwabe et al., 2005)
      Comments

      Expression of the moody+tgenα transgene restores viability of 20-25% of Df(1)moody-Δ17 flies but does not rescue the increased sensitivity to cocaine. This transgene restores the blood-brain barrier in all Df(1)moody-Δ17 flies.

      (Bainton et al., 2005)

      Expression of the moody+tgenα transgene provides significant rescue of the blood-brain barrier formation defect of Df(1)moody-Δ17 mutants.

      (Schwabe et al., 2005)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      moody+tgenα
      Name Synonyms
      Secondary FlyBase IDs
        References (3)