FB2024_03 , released June 25, 2024
Allele: Dmel\CRMPsupA4
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General Information
Symbol
Dmel\CRMPsupA4
Species
D. melanogaster
Name
FlyBase ID
FBal0195998
Feature type
allele
Associated gene
Dmel\CRMP
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Rawls, 2006)
Progenitor genotype
Cytology
Description

Nucleotide substitution: A?T.

(Rawls, 2006)

Amino acid replacement: D417V.

(Rawls, 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:5,577,915..5,577,915 [+]
Nucleotide change:

A5577915T

Reported nucleotide change:

A?T

Amino acid change:

D412V | CRMP-PA; D417V | CRMP-PE

Reported amino acid change:

D417V

Comment:

The reported amino acid change (D417V) is from Figure 6 of FBrf0192211 and does not agree with the D430V location reported in the text.

(Rawls, 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      CRMPsupA4/Df(3R)noi-B flies are more sensitive to 5-fluorouracil than control flies.

      (Rawls, 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      CRMPsupA4 is a suppressor of visible phenotype of bunspecified, rSu(b).cSa

      (Morris et al., 2012)
      Other
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      CRMPsupA4 is a suppressor of adult cuticle phenotype of bunspecified, rSu(b).cSa

      (Morris et al., 2012)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      CRMPsupA4 disrupts the suppression of the body colour phenotype of bunspecified mutants by rSu(b).cSa.

      CRMPfs9a.T:Avic\GFP-EGFP fails to support the suppression of the body colour phenotype of bunspecified, CRMPsupA4/CRMPsupK1 double mutants by rSu(b).cSa resulting in a dark gray cuticle.

      CRMPfs9b.T:Avic\GFP-EGFP supports the suppression of the body colour phenotype of bunspecified, CRMPsupA4/CRMPsupK1 double mutants by rSu(b).cSa resulting in a brownish cuticle.

      (Morris et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CRMPsupA4
      (Morris et al., 2012, Morris et al., 2012, Rawls, 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)