FB2024_03 , released June 25, 2024
Allele: Dmel\Sfmbt1
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General Information
Symbol
Dmel\Sfmbt1
Species
D. melanogaster
Name
FlyBase ID
FBal0196535
Feature type
allele
Associated gene
Dmel\Sfmbt
Associated Insertion(s)
TI{TI}Sfmbt1
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Klymenko et al., 2006)
Mutagen
recombination
(Klymenko et al., 2006)
I-SceI
(Klymenko et al., 2006)
FLPase
(Klymenko et al., 2006)
ends-out gene targeting
(Klymenko et al., 2006)
Progenitor genotype
Associated Insertion(s)
TI{TI}Sfmbt1
Caused by aberration
In(2L)Sfmbt1
Cytology
Description

Sfmbt 5' flanking and coding sequence (nucleotides 52991--53045, coordinates according to AE003639) has been replaced by a w+mW.hs marker and there is also an inversion and partial duplication of Sfmbt 3' coding sequences.

(Klymenko et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sfmbt1 homozygotes and Sfmbt1/Df(2L)BSC30 transheterozygote usually die as wandering third instar larvae. However, a small fraction of these larvae develop into highly abnormal prepupae that fail to develop further. At 120 hours AEL, both Sfmbt1 and Sfmbt1/Df(2L)BSC30 larvae have very small imaginal discs, although their body length is not different to wild-type larvae. Many of these animals continue to grow as wandering larvae, and their discs eventually develop into amorphous tumor-like tissue.

      Ovaries from females with Sfmbt1 mutant germ cells show an arrest during oogenesis.

      (Klymenko et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      ScmSuz302/ScmD1, Sfmbt1 has neoplasia | somatic clone phenotype

      (Grimm et al., 2009)
      Phenotype Manifest In
      Other
      Statement
      Reference

      ScmSuz302/ScmD1, Sfmbt1 has wing disc | somatic clone phenotype

      (Grimm et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sfmbt1 ScmD1/ScmSuz302 double mutant clones in the wing disc have a tumour-like phenotype that is characterized by unrestricted cell proliferation (this phenotype is not seen in single mutant clones).

      (Grimm et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Not rescued by

      Sfmbt1 is not rescued by SfmbtαTub84B.Tag:TAP

      (Alfieri et al., 2013)

      Df(2L)BSC30/Sfmbt1 is not rescued by SfmbtαTub84B.Tag:TAP

      (Alfieri et al., 2013)
      Comments

      Expression of SfmbtαTub84.T:Zzzz\TAP fails to rescue Sfmbt1 homozygotes or Sfmbt1/Df(2L)BSC30 transheterozygotes into viable adult flies.

      (Alfieri et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sfmbt1
      (Kang et al., 2022, Elizarev et al., 2021, Frey et al., 2016, Alfieri et al., 2013, Klymenko et al., 2006)
      dSfmbt1
      (Grimm et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)