FB2024_03 , released June 25, 2024
Allele: Dmel\HandEnR.UAS
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General Information
Symbol
Dmel\HandEnR.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0196561
Feature type
allele
Associated gene
Dmel\Hand
Associated Insertion(s)
Carried in Construct
P{UAS-Hand.EnR}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Han et al., 2006)
Progenitor genotype
Carried in construct
P{UAS-Hand.EnR}
Cytology
Description

UAS regulatory sequences drive expression of Hand coding sequences. The en repressor domain has been fused to the N-terminal end of the Hand coding region.

(Han et al., 2006)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hand
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Pan-mesodermal expression of HandScer\UAS.T:en-Rep, driven by both Scer\GAL4twi.PG and Scer\GAL4how-24B, disrupts embryonic heart formation. The number of cardioblasts and pericardial cells are reduced in these embryos. The residual cardiac cells are able to migrate to the dorsal midline at the end of embryogenesis, but their alignment is disrupted. In addition to the heart defects, the formation of lymph gland hematopoietic progenitor is completely blocked. Expression of HandScer\UAS.T:en-Rep under the control of Scer\GAL4HCH.Hand causes the same effects.

      (Han et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HandEnR.Scer\UAS
      HandEnR.UAS
      HandScer\UAS.T:Rep-en
      HandScer\UAS.T:en-Rep
      Name Synonyms
      Secondary FlyBase IDs
        References (1)