UASt regulatory sequences drive expression of an inverted repeat.
In males expressing ShGD13718 pan-neuronally, courtship of females is significantly decreased while male courtship is significantly increased, compared to controls.
Expression of ShGD13718 in the mushroom bodies under the control of Scer\GAL4Mef2.247 abolishes male discrimination in males.
Expression of ShGD13718 in various subsets of the peripheral taste neurons known to be involved in the sex pheromone response (under the control of one of Scer\GAL4Gr66a.PD, Scer\GAL4Gr68a.PB, Scer\GAL4Gr32a.3.776, or Scer\GAL4Gr33a-GAL4) results in high levels of sex discrimination in males. No alteration in female mating behavior is detected.
Adults expressing ShGD13718 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.