FB2024_03 , released June 25, 2024
Allele: Avic\GFPStat92E.10X
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General Information
Symbol
Avic\GFPStat92E.10X
Species
A. victoria
Name
FlyBase ID
FBal0211029
Feature type
allele
Associated gene
Avic\GFP
Associated Insertion(s)
Carried in Construct
P{10XStat92E-GFP}
Also Known As
10XSTAT92E-GFP, 10XSTAT-GFP, STAT92E-GFP, STAT-GFP, 10xStatGFP, 10XSTAT::GFP, 10XSTAT-dGFP, 10x STAT-GFP
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Bach et al., 2007, Ekas et al., 2006)
Progenitor genotype
Carried in construct
P{10XStat92E-GFP}
Cytology
Description

Five tandem repeats of a 441bp genomic region from the first intron of Socs36E, which contains two potential Stat92E binding sites, are cloned upstream of a minimal heat shock promoter driving expression of EGFP.

(Bach et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
Socs36E
Encoded product / tool
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage 14
      embryonic large intestine | restricted
      (Wells et al., 2013)
      second instar larval stage
      wing disc
      (Hatini et al., 2013)
      third instar larval stage
      wing disc | restricted
      (Hatini et al., 2013, Wells et al., 2013)
      adult stage
      adult brain | restricted
      (Rajan and Perrimon, 2012)
      adult optic lobe | restricted
      (Rajan and Perrimon, 2012)
      antennal lobe | restricted
      (Rajan and Perrimon, 2012)
      adult insulin secreting cell of pars intercerebralis
      (Rajan and Perrimon, 2012)
      adult brain cell body glial cell

      Comment: up-regulated in response to axotomy

      (Doherty et al., 2014)
      astrocyte-like glial cell
      (Doherty et al., 2014)
      intestinal stem cell of posterior adult midgut epithelium
      (Liu et al., 2010)
      enteroblast of posterior adult midgut epithelium
      (Liu et al., 2010)
      distribution deduced from reporter or direct label
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      third instar larval stage
      proventriculus | restricted

      Comment: foregut/midgut junction

      (Park and Kwon, 2011)
      Additional Information
      Statement
      Reference

      AvicGFPStat92E.10X is expressed in drpr and repo positive glial cells and is up-regulated in response to axotomy.

      (Doherty et al., 2014)

      AvicGFPStat92E.10X reporter activity is highly asymmetric within the anterior of the stage 14 large intestine. Cells on the inside of the hindgut curve show higher pathway activity than cells at comparable distances from the Upd-expressing large intestine on the outside of the curve. This difference in reporter activity is significant and not a consequence of increased cell density. Asymmetry in reporter activity is mirrored by expression of the endogenous JAK/STAT pathway target gene Socs36E.

      (Wells et al., 2013)

      In second instar larvae, reporter expression is observed throughout the disc proper. By early third instar, expression is repressed in the distal pouch and proximal notum,conincident with nub and eyg expression in these regions.

      (Hatini et al., 2013)

      A subset of the dorsomedial neurosecretory cells labelled by AvicGFPStat92E.10X also express ScerGAL4VGAT.PF.

      (Rajan and Perrimon, 2012)

      This GFP-reporter of JAK-STAT signaling is specifically expressed in the cells at the junction of the foregut and the midgut in third instar larvae.

      (Park and Kwon, 2011)

      Stat92E reporter is expressed in ISCs and enteroblasts.

      (Liu et al., 2010)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Avic\GFPStat92E.10X
      Name Synonyms
      Secondary FlyBase IDs
        References (65)