FlyBase Allele Report: Dmel\Gyc76C[KG03723]

General Information

Symbol

Dmel\Gyc76C^KG03723

Species

D. melanogaster

Name

FlyBase ID

FBal0213070

Feature type

allele

Associated gene

Dmel\Gyc76C

Associated Insertion(s)

P{SUPor-P}Gyc76C^KG03723

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{SUPor-P}Gyc76C^KG03723

Cytology

Description

A P{SUPor-P} element inserted in the 5' of the Gyc76C gene.

(Ayoob et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:19,793,069..19,793,069 [+]

(Ayoob et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response | adult stage

(Kanoh et al., 2021, Iwashita et al., 2020)

abnormal neuroanatomy

(Ayoob et al., 2004)

decreased occurrence of cell division | third instar larval stage | conditional

(Iwashita et al., 2020)

increased mortality | adult stage | conditional

(Kanoh et al., 2021, Iwashita et al., 2020)

Phenotype Manifest In

embryonic/larval hemocyte | third instar larval stage | conditional

(Iwashita et al., 2020)

larval abdominal segmental nerve

(Ayoob et al., 2004)

larval intersegmental nerve

(Ayoob et al., 2004)

Detailed Description

Statement

Reference

Gyc76C^KG03723 adults show increased susceptibility (i.e. mortality) to Gram-positive bacterial infections (Staphylococcus saprophyticus, Enterococcus faecalis, and Staphylococcus aureus), as well as higher bacterial loads in their hemolymph. Larvae are also susceptible to Staphylococcus saprophyticus infection.

(Kanoh et al., 2021)

Gyc76C^KG03723 adults exhibit increased mortality and accumulate Gram-positive bacterial loads in their hemolymph upon infection with S. saprophyticus, E. faecalis or S. aureus when compared to controls.

Gyc76C^KG03723 third instar larvae exhibit reduced hemocyte proliferation upon infection with E. coli or S. aureus when compared to controls.

(Iwashita et al., 2020)

Gyc76C^KG03723 embryos display an axon motor guidance phenotype in which ISNb and SNa axons sometimes fail to innervate their proper muscle targets.

(Ayoob et al., 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference