FlyBase Allele Report: Dmel\GSd427[GSd427]

General Information

Symbol

Dmel\GSd427^GSd427

Species

D. melanogaster

Name

FlyBase ID

FBal0218680

Feature type

allele

Associated gene

GSd427

Associated Insertion(s)

P{GSV1}GSd427^GSd427

Carried in Construct

Also Known As

GSd427

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GSV1}GSd427^GSd427

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GSV1}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

abnormal neuroanatomy | first instar larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Ou et al., 2008)

lethal, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007, Minidorff et al., 2007)

viable

(Houalla et al., 2010)

Phenotype Manifest In

dendrite | first instar larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Ou et al., 2008)

eye photoreceptor cell, with Scer\GAL4^GMR.PF

(Houalla et al., 2010)

larval intersegmental nerve, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

larval RP2 motor neuron | first instar larval stage | somatic clone, with Scer\GAL4^Act5C.PP

(Ou et al., 2008)

larval ventral nerve cord, with Scer\GAL4^scrt-11-6

(Minidorff et al., 2007)

Detailed Description

Statement

Reference

Expression of GSd427^GSd427 in the developing eye under the control of Scer\GAL4^GMR.PF generates a severe defect in R-cell positioning.

(Houalla et al., 2010)

Isolated RP2 neuron clones expressing GSd427^GSd427 under the control of Scer\GAL4^Act5C.PP (clones generated using the Scer\FLP1^eve.RN2 line) show a reduction in dendrite growth and branching at 25-31 hours after egg laying. The distribution of dendrites in the dendritic field is altered: there is a decrease in the number of dendrites targeted to the anterior, posterior, medial and lateral regions of the dendritic field.

(Ou et al., 2008)

Fas2-positive axon bundles in the ventral nerve cord are missing or disrupted and are diffuse or less distinct than normal in embryos expressing GSd427^GSd427 under the control of Scer\GAL4^scrt-11-6. In the periphery, the ISNb motor neuron is missing or thinned.

(Minidorff et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

GSd427^GSd427, Scer\GAL4^GMR.PF has eye photoreceptor cell phenotype, suppressible by RN-tre^GSV

(Houalla et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

A RN-tre^GSV background completely suppresses the R-cell mislocalization phenotype found upon expression of GSd427^GSd427 in the developing eye under the control of Scer\GAL4^GMR.PF.

(Houalla et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

GSd427

(Ou et al., 2008)

GSd427^GSd427

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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