FB2024_03 , released June 25, 2024
Allele: Dmel\GSd462GSd462
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General Information
Symbol
Dmel\GSd462GSd462
Species
D. melanogaster
Name
FlyBase ID
FBal0218721
Feature type
allele
Associated gene
GSd462
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
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        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Expression of GSd462GSd462 under the control of Scer\GAL4109(2)80 results in reduced dendrite growth in the dendritic arborisation neurons of the dorsal peripheral nervous system cluster in stage 17 embryos.

        Isolated RP2 neuron clones expressing GSd462GSd462 under the control of Scer\GAL4Act5C.PP (clones generated using the Scer\FLP1eve.RN2 line) show a reduction in dendrite branching at 25-31 hours after egg laying.

        (Ou et al., 2008)

        Fas2-positive axon bundles in the ventral nerve cord are missing or disrupted in embryos expressing GSd462GSd462 under the control of Scer\GAL4scrt-11-6. In the periphery, the ISNb, ISNd, SNa and SNc motor neurons are missing or thinned.

        (Minidorff et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
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        Additional Comments
        Genetic Interactions
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        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        The "GSd462" line contains two insertions (P{GSV1}GSd462a and P{GSV1}GSd462b) and it is not known which insertion is responsible for the lethality and other phenotypes seen in combination with the Scer\GAL4scrt-11-6 driver. FlyBase curator comment: a GSd462GSd462 allele has been made to accommodate the overexpression phenotypes, until it is known which (or both) insertions cause them.

        (Minidorff et al., 2007)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        GSd462
        (Ou et al., 2008)
        GSd462GSd462
        Name Synonyms
        Secondary FlyBase IDs
          References (3)