FB2024_02 , released April 23, 2024
Allele: Dmel\mAcon1MB09176
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General Information
Symbol
Dmel\mAcon1MB09176
Species
D. melanogaster
Name
FlyBase ID
FBal0219505
Feature type
allele
Associated gene
Dmel\mAcon1
Associated Insertion(s)
Mi{ET1}mAcon1MB09176
Carried in Construct
Also Known As
Mi{ET1}AconMB09176
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{ET1}mAcon1MB09176
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{ET1}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  Parkinson's disease
        modeled by Pink1B9
        (Esposito et al., 2013)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        mAcon1MB09176/Acon[+] is a suppressor | partially of abnormal flight phenotype of Pink1B9

        (Esposito et al., 2013)

        mAcon1MB09176, Drp1+t9.4, Acon[+] is a suppressor | partially of abnormal flight phenotype of Pink1B9

        (Esposito et al., 2013)
        NOT Suppressor of
        Statement
        Reference

        mAcon1MB09176/Acon[+] is a non-suppressor of abnormal flight phenotype of parkΔ21/park1

        (Esposito et al., 2013)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        mAcon1MB09176/Acon[+] is a suppressor | partially of mitochondrion phenotype of Pink1B9

        (Esposito et al., 2013)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The mitochondrial morphology defects seen in Pink1B9 adult flight muscles and dopaminergic neurons are significantly suppressed by AconMB09176/+. The flight defects of Pink1B9 adults are also significantly rescued.

        The mitochondria morphological defects seen in park1/parkΔ21 adults are not rescued by AconMB09176/+.

        Pink1B9 ; AconMB09176/+ ; Drp1+t9.4/+ animals show increased flight ability compared to either Pink1B9 ; AconMB09176/+ or Pink1B9 ; Drp1+t9.4/+ animals.

        (Esposito et al., 2013)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        mAcon1KO

        (Cheng et al., 2013)
        Rescued by

        mAcon1MB09176/mAcon11 is rescued by mAcon1+tCH322-18I04

        (Esposito et al., 2013)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        AconMB09176
        (Bellen, 2008.12.12)
        acon2
        (Esposito et al., 2013)
        mAcon1MB09176
        mAcon1mb09176
        (Cho et al., 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)