FlyBase Allele Report: Dmel\XNP[2]

General Information

Symbol

Dmel\XNP²

Species

D. melanogaster

Name

FlyBase ID

FBal0220139

Feature type

allele

Associated gene

Dmel\XNP

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Bassett et al., 2008)

Mutagen

Delta2-3 transposase

(Bassett et al., 2008)

Progenitor genotype

P{EP}XNP^EP635

(Bassett et al., 2008)

Cytology

Description

Imprecise excision of the P{EP}XNP^EP635 insertion, resulting in deletion of 238bp of the XNP promoter region, including the start of the XNP mRNA.

(Bassett et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal - majority die

(Bassett et al., 2008)

partially lethal - majority die (with XNP¹)

(López-Falcón et al., 2014)

partially lethal - majority live (with XNP³)

(López-Falcón et al., 2014)

suppressor of variegation | dominant, with In(1)w^m4h

(Bassett et al., 2008)

Phenotype Manifest In

Detailed Description

Statement

Reference

XNP¹/XNP² or XNP²/XNP³ flies have reduced viability and no melanotic masses (XNP¹/+, XNP²/+ or XNP³/+ flies are viable and have no melanotic masses).

(López-Falcón et al., 2014)

Paternal chromatin assembly occurs normally in eggs derived from XNP²/XNP³ females.

(Orsi et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ADD1^NP0793, XNP²/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP0793, XNP²/XNP³ has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP[+] has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP³ has melanotic mass phenotype | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP¹ has melanotic mass phenotype | larval stage phenotype

(López-Falcón et al., 2014)

Phenotype Manifest In

Other

Statement

Reference

ADD1^NP0793, XNP²/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP0793, XNP²/XNP³ has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP[+] has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP³ has melanotic mass | adult stage phenotype

(López-Falcón et al., 2014)

ADD1^NP1240, XNP²/XNP¹ has melanotic mass | larval stage phenotype

(López-Falcón et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

26643

w^*; XNP²/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

XNP²

atrx²

(López-Falcón et al., 2014)

dATRX²

(Bassett et al., 2008)

dxnp²

(Chavez et al., 2017)

xnp²

(Meyer-Nava et al., 2020, Orsi et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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