FlyBase Allele Report: Dmel\Mdr49[δ3.16]

General Information

Symbol

Dmel\Mdr49^δ3.16

Species

D. melanogaster

Name

FlyBase ID

FBal0220784

Feature type

allele

Associated gene

Dmel\Mdr49

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Mdr49^KG08611

(Ricardo and Lehmann, 2009)

Cytology

Description

Imprecise excision of P{}mdr49^KG08611 has deleted 3.4kb flanking the insertion site.

(Ricardo and Lehmann, 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

primordial germ cell

(Ricardo and Lehmann, 2009)

primordial germ cell (with Df(2R)Exel7123)

(Ricardo and Lehmann, 2009)

primordial germ cell (with Mdr49^KG08611)

(Ricardo and Lehmann, 2009)

Detailed Description

Statement

Reference

Somatic gonadal precursors are normally specified in Mdr49^δ3.16 homozygous embryos.

(Ricardo and Lehmann, 2009)

Germ cells in Mdr49^δ3.16 homozygous or Mdr49^δ3.16/Df(2R)Exel7123 embryos migrate through the posterior midgut, but many then fail to associate with somatic gonadal precursors. The same phenotype, but with fewer germ cells affected, is seen in Mdr49^δ3.16 heterozygotes and Mdr49^δ3.16/Mdr49^KG08611 embryos.

(Ricardo and Lehmann, 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

Mdr49^δ3.16 has primordial germ cell phenotype, suppressible | partially by Scer\GAL4^twi.PG

(Ricardo and Lehmann, 2009)

NOT Suppressor of

Statement

Reference

Mdr49[+]/Mdr49^δ3.16 is a non-suppressor of primordial germ cell | maternal effect | embryonic stage 5 phenotype of Neurl4^Δ1

(Jones and Macdonald, 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Ectopic migration of germ cells to the CNS in Hmgcr^{Scer\UAS.cvDa}; Scer\GAL4^elav-C155 embryos is partially suppressed by Mdr49^KG08611/+.

(Ricardo and Lehmann, 2009)

Xenogenetic Interactions

Statement

Reference

The germ cell migration defects seen in Mdr49^δ3.16 homozygous embryos are largely suppressed by Scer\STE6^{Scer\UAS,T:Avic\GFP}; Scer\GAL4^twi.PG.

(Ricardo and Lehmann, 2009)

Complementation and Rescue Data

Rescued by

Mdr49^δ3.16 is rescued by Scer\GAL4^twi.PG/Mdr49^UAS.cRa

(Ricardo and Lehmann, 2009)

Comments

Mdr49^Scer\UAS.cRa; Scer\GAL4^twi.PG rescues the germ cell migration phenotype due to Mdr49^δ3.16/Mdr49^δ3.16.

(Ricardo and Lehmann, 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Mdr49^δ3.16

(Ricardo and Lehmann, 2009)

mdr49^β3.16

(Jones and Macdonald, 2015)

mdr49^δ3.16

(Ricardo and Lehmann, 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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