FB2024_03 , released June 25, 2024
Allele: Dmel\gppGS17621
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General Information
Symbol
Dmel\gppGS17621
Species
D. melanogaster
Name
FlyBase ID
FBal0221176
Feature type
allele
Associated gene
Dmel\gpp
Associated Insertion(s)
P{GSV6}gppGS17621
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV6}gppGS17621
    Cytology
    Description

    Insertion in the 5'UTR.

    (List et al., 2009)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV6}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The mean adult lifespan of males expressing gppGS17621 under the control of Scer\GAL4hs.PB at 30[o]C is significantly shorter (34.5 +/- 0.8 days) than that of controls (36.7 +/- 0.7 days). These animals show no significant change in adult lifespan at 25[o]C.

        Flies expressing gppGS17621 under the control of Scer\GAL4hs.PB and transferred to a nutriment-poor medium 4 days after eclosion show an increased average lifespan compared to control flies, while flies expressing gppGS17621 under the control of Scer\GAL4hs.PB and transferred to a nutriment-poor medium 2 weeks after eclosion show a reduced average lifespan compared to control flies.

        Flies expressing gppGS17621 under the control of Scer\GAL4hs.PB show increased resistance to oxidative stress (1% hydrogen peroxide) compared to controls.

        Flies expressing gppGS17621 under the control of Scer\GAL4hs.PB (kept at 25[o]C for 4 days after eclosion and then maintained for 4 days at 30[o]C) show increased climbing activity compared to control flies.

        Flies expressing gppGS17621 under the control of Scer\GAL4hs.PB (kept at 25[o]C for 16 days after eclosion and then maintained for 4 days at 30[o]C) show increased climbing activity compared to control flies.

        (List et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        gppGS17621
        Name Synonyms
        Secondary FlyBase IDs
          References (1)