FB2024_03 , released June 25, 2024
Allele: Dmel\poloUASp.cXa
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General Information
Symbol
Dmel\poloUASp.cXa
Species
D. melanogaster
Name
FlyBase ID
FBal0221220
Feature type
allele
Associated gene
Dmel\polo
Associated Insertion(s)
Carried in Construct
P{UASp-polo.X}
Also Known As
UASp-polo
Key Links
Transgenic product class
wild_type
(Xiang et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Xiang et al., 2007)
Mutagen
in vitro construct
(Xiang et al., 2007)
Progenitor genotype
Carried in construct
P{UASp-polo.X}
Cytology
Description

UASp regulatory sequences drive expression of polo.

(Xiang et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
polo
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of poloScer\UAS.P\T.cXa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 results in a dosage-dependent increase in the frequency of achiasmate X and 4th chromosome nondisjunction in In(1)FM7/X females compared to controls (the In(1)FM7 chromosome is present to fully suppress X chromosomal exchange).

      (Xiang et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of poloScer\UAS.P\T.cXa under the control of Scer\GAL4tin.D partially rescues the severity of the cardiac defects seen in Df(3R)Exel6157 and in Df(1)CHES-1-like1 embryos. Both the defects in asymmetric cell division and in symmetric cell division seen in the cardiac progenitors are rescued.

      (Ahmad et al., 2012)

      The precocious nuclear envelope breakdown (NEB) seen in oocytes of mtrm126/+ females is enhanced by expression of poloScer\UAS.P\T.cXa under the control of Scer\GAL4nos.UTR.T:Hsim\VP16; the frequency of NEB in stage 12 oocytes is increased to 77%, and NEB is seen in 19% of stage 11 oocytes.

      (Xiang et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      poloScer\UAS.P\T.cXa
      poloUASp.cXa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)