moiCB02140/Tgs115-11 testes exhibit meiotic arrest with scattered PH3-positive cells.
Mitotic cells from the brains of homozygous, moi1/moiCB02140 and moiS096713/moiCB02140 larvae show frequent telomere fusions.
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has male sterile phenotype, suppressible by Tgs1+t4
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has male sterile phenotype, suppressible by Tgs1t4.moi-G45R
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has male sterile phenotype, suppressible by Tgs1GFP
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has male sterile phenotype, suppressible by Tgs1UAS.cCa/Scer\GAL4bam.PU
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has abnormal meiotic cell cycle phenotype, suppressible by Tgs1UAS.cCa/Scer\GAL4bam.PU
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has male sterile phenotype, suppressible by moit4.Tgs1-GFP
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has male sterile phenotype, non-suppressible by moiUAS.cCa/Scer\GAL4bam.PU
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has abnormal meiotic cell cycle phenotype, non-suppressible by moiUAS.cCa/Scer\GAL4bam.PU
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has viable phenotype
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has male sterile phenotype
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has abnormal meiotic cell cycle phenotype
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has female semi-sterile phenotype
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has testis phenotype, suppressible by Tgs1UAS.cCa/Scer\GAL4bam.PU
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has testis phenotype, non-suppressible by moiUAS.cCa/Scer\GAL4bam.PU
Tgs1CB02140/Tgs115-11, moiCB02140/moi15-11 has testis phenotype
moiCB02140/moi1 is rescued by moiR1.Tub
moiCB02140/moi1 is rescued by moiR2.Tub
moiCB02140/moi1 is rescued by moiR3.Tub
moiCB02140 is partially rescued by Scer\GAL4Act5C.PU/moiUAS.cCa
Associated with: tatlCB02140.
The P{PTT-GB}moiCB02140 insertion maps within a dicistronic locus that encodes moi (upstream ORF) and tatl (downstream ORF), being inserted in the moi ORF. Rescue analysis indicates that the telomere fusion phenotype seen in P{PTT-GB}moiCB02140 mutants is due to an effect on the moi ORF and not on tatl. In contrast, the lethality caused by the insertion is not rescued by a transgene containing either ORF alone, but is rescued by a transgene containing functional copies of both ORFs, indicating that the lethality is due to an effect on both ORFs.
Allelic series (with respect to severity of telomere fusion phenotype): moi1 > moiCB02140 = moiM12 > moiS096713.