FB2024_03 , released June 25, 2024
Allele: Dmel\EafRNAi.Sym.UAS
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General Information
Symbol
Dmel\EafRNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0221335
Feature type
allele
Associated gene
Dmel\Eaf
Associated Insertion(s)
Carried in Construct
P{Sym-UAS-Eaf}
Key Links
Transgenic product class
RNAi_reagent
(Smith et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Smith et al., 2008)
Mutagen
in vitro construct
(Smith et al., 2008)
Progenitor genotype
Carried in construct
P{Sym-UAS-Eaf}
Cytology
Description

Sense-antisense transcription of nucleotides 200-800 of the Eaf open reading frame (driven by two convergent arrays of UAS regulatory sequences) results in double stranded RNA (dsRNA) expression.

(Smith et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Eaf
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of EafdsRNA.Sym.Scer\UAS under the control of Scer\GAL4Act5C.PU results in a significant reduction in the number of adult progeny obtained compared to controls. In addition, there is a consistent reduction in the male-female sex ratio observed for the adult escapers.

      Expression of P{Sym-UAS-Eaf} (which carries both EafSym.Scer\UAS and Eafa.Sym.Scer\UAS) under the control of Scer\GAL4Act5C results in a significant reduction in the number of adult progeny obtained compared to controls. In addition, there is a consistent reduction in the male-female sex ratio observed for the adult escapers.

      (Smith et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Associated with: Eafa.Sym.Scer\UAS.

      (Smith et al., 2008)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      EafRNAi.Sym.UAS
      EafSym.Scer\UAS
      EafdsRNA.Sym.Scer\UAS
      EafdsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0221336
      References (2)