FB2024_03 , released June 25, 2024
Allele: Dmel\CirlKK108383
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General Information
Symbol
Dmel\CirlKK108383
Species
D. melanogaster
Name
FlyBase ID
FBal0235534
Feature type
allele
Associated gene
Dmel\Cirl
Associated Insertion(s)
Carried in Construct
P{KK108383}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK108383}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK108383
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  attention deficit hyperactivity disorder
      CEA
      (van der Voet et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CirlKK108383 (along with UAS-dicer2 to enhance RNAi efficiency) driven by Scer\GAL4elav.PU results in significant hyperactivity and sleep loss (particularly at night), compared to control flies. Expression of CirlKK108383 (along with UAS-dicer2 to enhance RNAi efficiency) driven by Scer\GAL4nSyb.PU results in significant hyperactivity. In constant darkness, Scer\GAL4elav.PU>CirlKK108383 flies show equally significant increases in activity and decreases in sleep during both the relative day and night. Scer\GAL4elav.PU>CirlKK108383 flies have similar numbers of dopaminergic neurons as controls at 5 and 11 days old.

      (van der Voet et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      CirlKK108383
      Name Synonyms
      Secondary FlyBase IDs
        References (5)