FlyBase Allele Report: Dmel\Inx2[KK111067]

General Information

Symbol

Dmel\Inx2^KK111067

Species

D. melanogaster

Name

FlyBase ID

FBal0237195

Feature type

allele

Associated gene

Dmel\Inx2

Associated Insertion(s)

Carried in Construct

P{KK111067}

Also Known As

KK111067

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK111067}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK111067

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

(Tsubouchi et al., 2012)

lethal - all die before end of larval stage, with Scer\GAL4^repo.PL

(Volkenhoff et al., 2018)

lethal - all die during embryonic stage, with Scer\GAL4^repo

(Chaturvedi et al., 2014)

semi-sterile, with Scer\GAL4^tj.PU

(Smendziuk et al., 2015)

viable, with Scer\GAL4^elav-C155

(Chaturvedi et al., 2014)

Phenotype Manifest In

female germline cell, with Scer\GAL4^C587

(Mukai et al., 2011)

germarium, with Scer\GAL4^C587

(Mukai et al., 2011)

ovary, with Scer\GAL4^C587

(Mukai et al., 2011)

Detailed Description

Statement

Reference

Expression of Inx2^KK111067 under the control of Scer\GAL4^ey-OK107 in adults does not significantly affect 3 hour aversive olfactory memory or the residual anaesthesia-resistant memory (ARM) after cold-shock, compared to controls; expression under the control of Scer\GAL4^VT000765 also does not affect ARM, compared to controls.

(Shyu et al., 2019)

Expression of Inx2^KK111067 under the control of Scer\GAL4^17d, the split-GAL4 pair of Scer\GAL4^DBD.R41C07 and Hsap\RELA^AD.R13F02, the split-GAL4 pair of Scer\GAL4^DBD.R89B01 and Hsap\RELA^AD.R13F02, or the split-GAL4 pair of Scer\GAL4^DBD.R14C08 and Hsap\RELA^AD.R12C11, does not affect visual short term memory following training with pain stimulus in adult flies, compared to controls.

(Liu et al., 2016)

Expression of Inx2^KK111067 under the control of Scer\GAL4^tj.PU (along with expression of UAS-Dcr2 to increase RNAi efficiency) results in semi-sterility.

(Smendziuk et al., 2015)

Neuronal expression of Inx2^KK111067 under the control of Scer\GAL4^elav-C155 does not affect fly viability or visual signal transmission.

(Chaturvedi et al., 2014)

Expression of Inx2^KK111067 under the control of Scer\GAL4^C587 results in ovaries arresting in early oogenesis. The germaria in these females appear to contain only early germ cells with single spectrosomes. The number of germ cells is reduced.

(Mukai et al., 2011)

Expression of inx2^KK111067 in both the anterior paired lateral (APL) and dorsal paired medial (DPM) neurons in the mushroom body (using the Scer\GAL4^GH146 and Scer\GAL4^c316 drivers simultaneously) has no effect on 3 hour memory after associative conditioning.

(Wu et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

Inx2^KK111067 is partially rescued by Inx2^UAS.EGFP/Scer\GAL4^repo

(Chaturvedi et al., 2014)

Comments

Expression of Inx2^{Scer\UAS.T:Avic\GFP-EGFP} in glia, under the control of Scer\GAL4^repo, partially rescues flies expressing Inx2^KK111067 under the control of Scer\GAL4^repo. These rescued flies show normal visual transmission, excluding a role of neuronal Inx2 in visual transmission.

(Chaturvedi et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102194

P{KK111067}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Inx2^KK111067

inx2^KK111067

(Smendziuk et al., 2015)

inx2^dsRNA

(Kottmeier et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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