FlyBase Allele Report: Dmel\AGO3[t3]

General Information

Symbol

Dmel\AGO3^t3

Species

D. melanogaster

Name

FlyBase ID

FBal0239064

Feature type

allele

Associated gene

Dmel\AGO3

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Li et al., 2009)

Progenitor genotype

Cytology

Description

Amino acid replacement: W452term.

(Li et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:23,569,528..23,569,528 [+]

Nucleotide change:

G23569528A

Amino acid change:

W452term | AGO3-PD; W452term | AGO3-PE; W452term | AGO3-PF; W452term | AGO3-PG

Reported amino acid change:

W452term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase base on reported amino acid change.

(Li et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by caz^VDRC.cUa

(Wakisaka et al., 2019)

modeled by caz^HMS00790

(Wakisaka et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with AGO3^t2)

(Li et al., 2009)

male semi-sterile (with AGO3^t2)

(Li et al., 2009)

viable

(Li et al., 2009)

viable (with AGO3^t1)

(Li et al., 2009)

viable (with AGO3^t2)

(Li et al., 2009)

viable (with Df(3L)TTT)

(Li et al., 2009)

Phenotype Manifest In

dorsal appendage | maternal effect (with AGO3^t2)

(Li et al., 2009)

egg | maternal effect (with AGO3^t2)

(Li et al., 2009)

Detailed Description

Statement

Reference

AGO3^t2/AGO3^t3 females are sterile, initially laying far fewer eggs than their control siblings and stopping laying altogether by stage 10. None of the eggs laid by these females hatch and many of them have fused or missing dorsal appendages.

AGO3^t2/AGO3^t3 males are semifertile, siring fewer offspring than do control males with the same genetic background. Ste protein crystals form in primary spermatocytes in AGO3^t2/AGO3^t3 testes.

(Li et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

AGO3^t3 is a non-suppressor of neoplasia phenotype of l(3)mbt^ts1

(Janic et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The frequency with which l(3)mbt^ts1 larval brain tissue develops into tumours after allograft into adult host flies (taking over the entire abdomen of the host) is not significantly altered if the transplanted tissue is also homozygous for AGO3^t3.

(Janic et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28270

bw¹; st¹ AGO3^t3/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

AGO3^T3

(Teixeira et al., 2017)

AGO3^t3

(Wakisaka et al., 2019, Minakhina et al., 2014, Janic et al., 2010)

Ago3^T3

(Yang et al., 2015)

ago3^T3

(Venkei et al., 2023)

ago3^t3

(Iki et al., 2023, Lin et al., 2023, Lim et al., 2022, Andress et al., 2016, Wang et al., 2015, Patil et al., 2014, Perrat et al., 2013, Anand and Kai, 2012, Kibanov et al., 2011, Zhang et al., 2011, Nagao et al., 2010, Patil and Kai, 2010, Rouget et al., 2010, Li et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (20)

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